entity 584 words KG: autophagy
Contents

Autophagy

🔬 Protein Info
Gene Symbolautophagy
AliasesAutophagy-lysosomal pathway, Cellular self-eating
FunctionProtein degradation; Organelle turnover; Quality control
PathwaysmTOR pathway, AMPK signaling, Beclin-1 complex
Associated Diseasesadipogenesis, ALS, Alzheimer's disease, Alzheimer's disease and related dementias, AMD, amyotrophic lateral sclerosis
Known Drugs/Compoundsarsenic, ATTECs, calycosin, Calycosin, CDK4/6 inhibitors, cocaine
KG Connections718 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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Related Hypotheses (118)

Vagal Afferent Microbial Signal Modulation
Score: 0.62
TREM2-mediated microglial tau clearance enhancement
Score: 0.62
Low Complexity Domain Cross-Linking Inhibition
Score: 0.62
Trinucleotide Repeat Sequestration via CRISPR-Guided RNA Tar
Score: 0.61
The Glial Ketone Metabolic Shunt Hypothesis
Score: 0.61
Metabolic Reprogramming via Coordinated Multi-Gene CRISPR Ci
Score: 0.60
VCP-Mediated Autophagy Enhancement
Score: 0.59
CX43 hemichannel engineering enables size-selective mitochon
Score: 0.57
Astroglial Gap Junction Coordination via Connexin-43 Phospho
Score: 0.57
Liquid-Liquid Phase Separation Modifier Therapy
Score: 0.55
HSP70 Co-chaperone DNAJB6 Universal Cross-Seeding Inhibitor
Score: 0.54
Temporal Decoupling via Circadian Clock Reset
Score: 0.54
Cryptic Exon Silencing Restoration
Score: 0.53
PINK1/Parkin-Independent Mitophagy Bypass for Enhanced Donor
Score: 0.53
Piezoelectric Nanochannel BBB Disruption
Score: 0.52
Microbial Metabolite-Mediated α-Synuclein Disaggregation
Score: 0.51
Microglia-Derived Extracellular Vesicle Engineering for Targ
Score: 0.48
Prohibitin-2 Mitochondrial Cross-Seeding Hub Disruption
Score: 0.47
← Prevpg 6/6

Related Analyses (30)

How do non-cell autonomous effects of autophagy dysfunction
neurodegeneration · completed
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Epigenetic reprogramming in aging neurons
neurodegeneration · archived
Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived

Related Experiments (30)

P2RY12 regulation of autophagy in VSMCs
exploratory · proposed · Score: 0.90
Autophagy receptor identification for stress granule elimina
exploratory · proposed · Score: 0.90
Trehalose-induced lysosomal changes and TFEB activation
exploratory · proposed · Score: 0.90
iPSC-NPC effects on astrocytes in vitro ICH model
exploratory · completed · Score: 0.90
Trehalose-induced lysosomal membrane permeabilization and TF
exploratory · proposed · Score: 0.90

See Also (4)

ABCA7 (Redirect)
redirect · KG edge: associated_with
ABCA1 - ATP-Binding Cassette Transporter A1
gene · KG edge: activates
ABCD3 Gene
gene · KG edge: interacts_with
ABCG1 Gene
gene · KG edge: co_discussed

Knowledge Graph (12 edges)

autophagy regulates ferroptosis
ULK1 activates autophagy
autophagy activates bacterial_clearance
autophagy activates NRF2
autophagy treats neurodegeneration
autophagy regulates intestinal_epithelium
autophagy regulates tight_junctions
autophagy activates barrier_function
autophagy regulates intestinal_stem_cells
autophagy regulates secretory_cells

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