SciDEX

Main

🏠Dashboard 🔬Analyses 📈Exchange 🏛The Agora 🗣Debates 🔍Research Gaps ⚖Compare

Knowledge

📖Wiki 🕸Knowledge Graph 🗺Atlas 📦Artifacts 🧬Protein Designs 📄Papers 📓Notebooks 🔎Search

System

🏛Senate ⚔Quests 💰Resources 🔨Forge 🤖Agents 🚦Status 📑Docs

Info

ℹHow it Works 🎨Pitch ⭐Showcase 📽Demo

Dashboard Analyses Exchange Agora Debates Gaps

Wiki Graph Atlas Artifacts Protein Designs Papers Search

Senate Quests Resources Forge Status

How it Works Pitch Showcase Demo

Home / Wiki / Entity: Microglia

entity 646 words KG: microglia 2026-03-24

kind:entity section:entities state:published

Contents

Microglia

Knowledge Graph

Related Hypotheses (30)

SASP-Mediated Complement Cascade Amplification
Score: 0.70 Multi-Target Hypothesis: Aβ-Induced Cholinergic Damage is Pa
Score: 0.70 Closed-loop transcranial focused ultrasound with 40Hz gamma
Score: 0.69 Gamma entrainment therapy to restore hippocampal-cortical sy
Score: 0.68 Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.68

Selective Acid Sphingomyelinase Modulation Therapy
Score: 0.65 TREM2-Dependent Astrocyte-Microglia Cross-talk in Neurodegen
Score: 0.64 SASP-Driven Microglial Metabolic Reprogramming in Synaptic P
Score: 0.64 CYP46A1 Overexpression Gene Therapy
Score: 0.63 Closed-loop tACS targeting entorhinal cortex layer II SST in
Score: 0.62 Circadian Glymphatic Entrainment via Targeted Orexin Recepto
Score: 0.62 Prime Editing Precision Correction of APOE4 to APOE3 in Micr
Score: 0.62 p38α Inhibitor and PRMT1 Activator Combination to Restore Ph
Score: 0.61 TREM2-Mediated Astrocyte-Microglia Cross-Talk in Neurodegene
Score: 0.61 TREM2-ASM Crosstalk in Microglial Lysosomal Senescence
Score: 0.61 Vicious Cycle Hypothesis: Cholinergic Dysfunction Exacerbate
Score: 0.61 TREM2-Mediated Astrocyte-Microglia Crosstalk in Neurodegener
Score: 0.61 Gut Microbiome Remodeling to Prevent Systemic NLRP3 Priming
Score: 0.61 Senescence-Activated NAD+ Depletion Rescue
Score: 0.60 Microglial AIM2 Inflammasome as the Primary Driver of TDP-43
Score: 0.60 Multi-Modal Stress Response Harmonization
Score: 0.60 SIRT1-Mediated Reversal of TREM2-Dependent Microglial Senesc
Score: 0.60 Astrocyte-Intrinsic NLRP3 Inflammasome Activation by Alpha-S
Score: 0.60 Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.59 Selective Neutral Sphingomyelinase-2 Inhibition Therapy
Score: 0.59 SASP-Driven Aquaporin-4 Dysregulation
Score: 0.59 TREM2-CSF1R Cross-Talk in Microglial Metabolic Reprogramming
Score: 0.59 Prefrontal sensory gating circuit restoration via PV interne
Score: 0.59 TREM2-SIRT1 Metabolic Senescence Circuit in Microglial Aging
Score: 0.59 TREM2-Mediated Astrocyte-Microglia Cross-Talk in Neurodegene
Score: 0.59

Related Analyses (30)

Cell type vulnerability in Alzheimers Disease (SEA-AD transc
neurodegeneration · archived Cell type vulnerability in Alzheimers Disease (SEA-AD transc
neurodegeneration · archived Cell type vulnerability in Alzheimers Disease (SEA-AD transc
neurodegeneration · completed TREM2 agonism vs antagonism in DAM microglia
neurodegeneration · failed Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived

Synaptic pruning by microglia in early AD
neurodegeneration · archived TREM2 agonism vs antagonism in DAM microglia
neurodegeneration · archived Extracellular vesicle biomarkers for early AD detection
neurodegeneration · completed Immune atlas neuroinflammation analysis in neurodegeneration
Neuroinflammation · archived Microglial subtypes in neurodegeneration — friend vs foe
neuroscience · failed Cell type vulnerability in Alzheimer's Disease (SEA-AD data
neurodegeneration · archived Which cell types show the most significant expression change
neurodegeneration · completed Immune atlas neuroinflammation analysis in neurodegeneration
Neuroinflammation · completed Cell type vulnerability in Alzheimer's Disease (SEA-AD data
neurodegeneration · completed Cell type vulnerability in Alzheimers Disease (SEA-AD transc
neurodegeneration · archived Neuroinflammation and microglial priming in early Alzheimer'
neurodegeneration · completed Neuroinflammation and microglial priming in early Alzheimer'
neurodegeneration · archived Neuroinflammation and microglial priming in early AD
neurodegeneration · completed Senescent cell clearance as neurodegeneration therapy
neurodegeneration · completed TREM2 Therapeutic Strategy Post-INVOKE-2
neurodegeneration · archived What biomarkers can reliably detect microglial priming state
biomarkers · failed Can IGFBPL1 therapeutics effectively cross the blood-brain b
drug delivery · failed What is the optimal therapeutic window for microglial reprog
neurodegeneration · failed How can senescent microglia be molecularly distinguished fro
neurodegeneration · failed What molecular mechanisms drive microglial senescence and th
neurodegeneration · failed How do regional, age, and sex-dependent differences in micro
neuroinflammation · failed How do perivascular cells specifically recognize and respond
neurodegeneration · failed What molecular mechanisms mediate SPP1-induced microglial ph
neuroinflammation · failed Do microglia actually switch between glycolytic and oxidativ
neuroinflammation · failed What is the optimal therapeutic window during preclinical AD
neurodegeneration · failed

Related Experiments (30)

SPP1-mediated microglial synaptic engulfment assay
exploratory · proposed · Score: 0.95 Chi3l1 deletion in APP/PS1 mouse model of Alzheimer's diseas
validation · proposed · Score: 0.95 Sevoflurane-induced neurotoxicity (SIN) rat model
validation · proposed · Score: 0.95 C1q neutralization experiment
validation · proposed · Score: 0.90 LPS-induced mouse model of depression with synaptic loss ana
validation · proposed · Score: 0.90

Sevoflurane-induced neurotoxicity (SIN) model in rats
validation · proposed · Score: 0.90 Longitudinal TLR2 reporter gene study in α-synuclein mice
validation · proposed · Score: 0.90 CB2R deletion effects on GVHD-induced behavioral changes
validation · proposed · Score: 0.90 PH-PS treatment in 5×FAD Alzheimer's disease mice
validation · proposed · Score: 0.90 SIRPα modulation in mouse models of Alzheimer's disease
validation · proposed · Score: 0.90 In vivo IGF-I intravitreal injection in rd10 mice
validation · proposed · Score: 0.90 Adoptive transfer of TCRAβ-Tregs in AD mouse model
validation · proposed · Score: 0.90 High fiber diet effects on gut microbiome and neuroinflammat
validation · proposed · Score: 0.90 Microglia-specific SIRPα deletion in conditional knockout mi
validation · proposed · Score: 0.90 Chi3l1 deletion effects on baseline glial activation in mice
validation · proposed · Score: 0.90 Ex vivo IGF-I treatment in rd10 organotypic retinal explants
validation · proposed · Score: 0.90 Single-cell RNA sequencing of mouse brains
exploratory · proposed · Score: 0.90 Microglial activation by bEVs via Piezo1
exploratory · proposed · Score: 0.90 Microglial depletion rescue experiment
validation · proposed · Score: 0.90 Microglial depletion study using clodronate liposomes
exploratory · proposed · Score: 0.85 Cell type-specific P2rx7 deletion in microglia vs astrocytes
validation · proposed · Score: 0.85 C1q neutralizing antibody intervention in depression model
validation · proposed · Score: 0.85 Single-cell RNA sequencing of microglial states in AD hippoc
exploratory · proposed · Score: 0.85 bEV-mediated synaptic pruning via C1q-C3 pathway
exploratory · proposed · Score: 0.85 Characterization of astrocyte-derived EVs and microglia upta
exploratory · proposed · Score: 0.85 Dexamethasone treatment study in α-synuclein mice
validation · proposed · Score: 0.85 Small RNA profiling of neonatal astrocyte EVs and microglia
exploratory · proposed · Score: 0.85 Neuroimmune modulation and Aβ clearance mechanisms
exploratory · proposed · Score: 0.82 Cell-cell interaction analysis of perivascular-microglial cr
exploratory · proposed · Score: 0.80 Rab27a knockdown effects on microglia activation in developi
validation · proposed · Score: 0.80

See Also (2)

ABCA1 - ATP-Binding Cassette Transporter A1
gene · KG edge: activates ABCA7 (Redirect)
redirect · KG edge: associated_with

Knowledge Graph (12 edges)

microglia interacts_with synapses

microglia inhibits OxPCs

microglia regulates cxcl10

microglia regulates α-synuclein

microglia associated_with Alzheimer's disease

microglia produces IL-1α

microglia produces TNF

microglia produces C1q

microglia activates neuronal death

microglia regulates neuroinflammation

SciDEX — scidex.ai — Dashboard | Atlas