concept

GFP

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GFP: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1010Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

GFP is a concept in neurodegeneration research. Key relationships include: associated with, activates, inhibits. Associated with AD, ALI, ALS. Connected to 429 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	GFP
Key Genes/Proteins	ABL1, ABP, ACETYL-COA, ACLY, ACTB, Actin
Related Diseases	AD, Aging, ALI, Als
Related Pathways	Akt

Pathway Diagram

graph TD
    GFP["GFP"]
    GFP -->|"expressed in"| microglia["microglia"]
    GFP -->|"interacts"| Amyotrophic_Lateral_Sclerosis["Amyotrophic Lateral Sclerosis"]
    GFP -->|"interacts"| ALS["ALS"]
    GFP -->|"interacts"| Dementia["Dementia"]
    GFP -->|"activates"| Tumor["Tumor"]
    GFP -->|"degrades"| Aging["Aging"]
    GFP -->|"degrades"| Cardiovascular["Cardiovascular"]
    GFP -->|"inhibits"| Inflammation["Inflammation"]
    C9ORF72["C9ORF72"] -->|"interacts"| GFP
    LC3["LC3"] -->|"interacts"| GFP
    P62["P62"] -->|"interacts"| GFP
    FUS["FUS"] -->|"interacts"| GFP
    UBIQUITIN["UBIQUITIN"] -->|"interacts"| GFP
    SQSTM1["SQSTM1"] -->|"interacts"| GFP
    TRIM21["TRIM21"] -->|"interacts"| GFP
    OPTN["OPTN"] -->|"interacts"| GFP
    NEURODEGENERATIVE_DISEASES["NEURODEGENERATIVE DISEASES"] -->|"regulates"| GFP
    ACTB["ACTB"] -->|"interacts"| GFP

Outgoing (700)

Target	Relation	Type	Str
GFP	encodes	protein	0.00
LC3	associated_with	gene	1.00
AUTOPHAGY	associated_with	gene	1.00
Autophagy	associated_with	pathway	1.00
Autophagy	activates	pathway	1.00
AUTOPHAGY	activates	gene	1.00
MTOR	activates	gene	1.00
Mtor	activates	pathway	1.00
Tumor	activates	disease	0.95
oxidative stress response	participates_in	pathway	0.90
autophagy pathway	participates_in	pathway	0.90
AKT	activates	gene	0.90
Aging	inhibits	disease	0.85
Infection	activates	disease	0.85
Als	activates	disease	0.85
MCOLN1	activates	gene	0.80
neural stem cells	activates	cell_type	0.80
neurons	regulates	cell_type	0.80
apoptosis pathway	participates_in	pathway	0.80
ubiquitin-proteasome	participates_in	pathway	0.80
Pi3K/Akt	activates	pathway	0.80
PI3K	activates	gene	0.80
APOPTOSIS	activates	gene	0.80
Apoptosis	activates	pathway	0.80
AMPK	activates	gene	0.80
Apoptosis	associated_with	pathway	0.80
Mtor	associated_with	pathway	0.80
LC3	activates	gene	0.80
Inflammation	activates	disease	0.75
Cancer	therapeutic_target	disease	0.75
Als	associated_with	disease	0.75
Cancer	associated_with	disease	0.75
Tumor	inhibits	disease	0.75
ATG	associated_with	gene	0.70
neurons	disrupts	cell_type	0.70
MCOLN1	interacts_with	gene	0.70
adenosine	activates	neurotransmitter	0.70
Mtor	inhibits	pathway	0.70
microglia	expressed_in	cell_type	0.70
DMSO	associated_with	gene	0.70
blood-brain barrier	participates_in	pathway	0.70
hippocampus	expressed_in	brain_region	0.70
MAP1LC3	activates	gene	0.70
SQSTM1	regulates	gene	0.70
P62	associated_with	gene	0.70
ATG5	activates	gene	0.70
SQSTM1	activates	gene	0.70
BECN1	associated_with	gene	0.70
neurons	expressed_in	cell_type	0.70
RNA	regulates	gene	0.70

Incoming (310)

Source	Relation	Type	Str
GFP	encodes	gene	0.00
rapamycin	targets	drug	0.80
BECN1	associated_with	gene	0.70
DNA	activates	gene	0.70
CASP3	activates	gene	0.70
CTSB	interacts_with	gene	0.70
CTSD	interacts_with	gene	0.70
CTSB	activates	gene	0.70
CTSD	activates	gene	0.70
AMPK	interacts_with	gene	0.70
CALCOCO2	regulates	gene	0.70
SQSTM1	associated_with	gene	0.70
BECN1	activates	gene	0.70
BNIP3L	associated_with	gene	0.60
APOPTOSIS	associated_with	gene	0.60
PRKN	associated_with	gene	0.60
MITOPHAGY	degrades	gene	0.60
TOMM20	associated_with	gene	0.60
PARKIN	associated_with	gene	0.60
LC3B	associated_with	gene	0.60
COX4I1	associated_with	gene	0.60
AGING	degrades	gene	0.60
OPTINEURIN	associated_with	gene	0.60
WIPI2	associated_with	gene	0.60
CALCOCO2	associated_with	gene	0.60
INS	associated_with	gene	0.60
PARKINSON	associated_with	gene	0.60
TFEB	associated_with	gene	0.60
PIK3C3	associated_with	gene	0.60
TBK1	associated_with	gene	0.60
NBR1	associated_with	gene	0.60
TGFB	associated_with	gene	0.60
MAPK	associated_with	gene	0.60
GBA	regulates	gene	0.60
ACTB	regulates	gene	0.60
GAPDH	regulates	gene	0.60
NRF2	regulates	gene	0.60
HMOX1	regulates	gene	0.60
ATG5	regulates	gene	0.60
GAPDH	activates	gene	0.60
SYNAPSE	expressed_in	gene	0.60
OPA1	expressed_in	gene	0.60
NEURODEGENERATION	expressed_in	gene	0.60
MITOCHONDRIAL DYSFUNCTION	expressed_in	gene	0.60
SREBP1	activates	gene	0.60
MICROGLIA	expressed_in	gene	0.60
ACTB	activates	gene	0.60
ALS	activates	gene	0.60
CALCOCO2	activates	gene	0.60
FUS	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning GFP in their description or question text

No additional research found