Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about GFP: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
GFP is a concept in neurodegeneration research. Key relationships include: associated with, activates, inhibits. Associated with AD, ALI, ALS. Connected to 429 entities in the SciDEX knowledge graph.
| Name | GFP |
| Key Genes/Proteins | LC3, AUTOPHAGY, MTOR, AKT |
| Related Diseases | Tumor, Aging, Als, Infection |
| Related Pathways | Autophagy, Mtor, oxidative stress response, autophagy pathway, ubiquitin-proteasome |
Knowledge base pages for this entity
graph TD
GFP["GFP"]
GFP -->|"expressed in"| microglia["microglia"]
GFP -->|"interacts"| Amyotrophic_Lateral_Sclerosis["Amyotrophic Lateral Sclerosis"]
GFP -->|"interacts"| ALS["ALS"]
GFP -->|"interacts"| Dementia["Dementia"]
GFP -->|"activates"| Tumor["Tumor"]
GFP -->|"degrades"| Aging["Aging"]
GFP -->|"degrades"| Cardiovascular["Cardiovascular"]
GFP -->|"inhibits"| Inflammation["Inflammation"]
C9ORF72["C9ORF72"] -->|"interacts"| GFP
LC3["LC3"] -->|"interacts"| GFP
P62["P62"] -->|"interacts"| GFP
FUS["FUS"] -->|"interacts"| GFP
UBIQUITIN["UBIQUITIN"] -->|"interacts"| GFP
SQSTM1["SQSTM1"] -->|"interacts"| GFP
TRIM21["TRIM21"] -->|"interacts"| GFP
OPTN["OPTN"] -->|"interacts"| GFP
NEURODEGENERATIVE_DISEASES["NEURODEGENERATIVE DISEASES"] -->|"regulates"| GFP
ACTB["ACTB"] -->|"interacts"| GFP| Target | Relation | Type | Str |
|---|---|---|---|
| LC3 | associated_with | gene | 1.00 |
| AUTOPHAGY | associated_with | gene | 1.00 |
| Autophagy | associated_with | pathway | 1.00 |
| AUTOPHAGY | activates | gene | 1.00 |
| Autophagy | activates | pathway | 1.00 |
| MTOR | activates | gene | 1.00 |
| Mtor | activates | pathway | 1.00 |
| Tumor | activates | disease | 0.95 |
| oxidative stress response | participates_in | pathway | 0.90 |
| autophagy pathway | participates_in | pathway | 0.90 |
| AKT | activates | gene | 0.90 |
| Aging | inhibits | disease | 0.85 |
| Als | activates | disease | 0.85 |
| Infection | activates | disease | 0.85 |
| ubiquitin-proteasome | participates_in | pathway | 0.80 |
| apoptosis pathway | participates_in | pathway | 0.80 |
| neural stem cells | activates | cell_type | 0.80 |
| neurons | regulates | cell_type | 0.80 |
| MCOLN1 | activates | gene | 0.80 |
| Mtor | associated_with | pathway | 0.80 |
| Apoptosis | associated_with | pathway | 0.80 |
| PI3K | activates | gene | 0.80 |
| Pi3K/Akt | activates | pathway | 0.80 |
| AMPK | activates | gene | 0.80 |
| LC3 | activates | gene | 0.80 |
| APOPTOSIS | activates | gene | 0.80 |
| Apoptosis | activates | pathway | 0.80 |
| Cancer | associated_with | disease | 0.75 |
| Tumor | inhibits | disease | 0.75 |
| Cancer | therapeutic_target | disease | 0.75 |
| Inflammation | activates | disease | 0.75 |
| Als | associated_with | disease | 0.75 |
| microglia | expressed_in | cell_type | 0.70 |
| P62 | associated_with | gene | 0.70 |
| MAP1LC3 | associated_with | gene | 0.70 |
| BECN1 | associated_with | gene | 0.70 |
| BCL2 | associated_with | gene | 0.70 |
| MTOR | associated_with | gene | 0.70 |
| DMSO | associated_with | gene | 0.70 |
| UBIQUITIN | associated_with | gene | 0.70 |
| Mtor | inhibits | pathway | 0.70 |
| AUTOPHAGY | therapeutic_target | gene | 0.70 |
| APOPTOSIS | therapeutic_target | gene | 0.70 |
| CANCER | therapeutic_target | gene | 0.70 |
| GENES | therapeutic_target | gene | 0.70 |
| Autophagy | therapeutic_target | pathway | 0.70 |
| Apoptosis | therapeutic_target | pathway | 0.70 |
| APOPTOSIS | associated_with | gene | 0.70 |
| BCL-2 | activates | gene | 0.70 |
| MITOPHAGY | activates | gene | 0.70 |
| Source | Relation | Type | Str |
|---|---|---|---|
| rapamycin | targets | drug | 0.80 |
| SQSTM1 | associated_with | gene | 0.70 |
| BECN1 | associated_with | gene | 0.70 |
| BECN1 | activates | gene | 0.70 |
| CALCOCO2 | regulates | gene | 0.70 |
| CASP3 | activates | gene | 0.70 |
| CTSB | activates | gene | 0.70 |
| CTSD | activates | gene | 0.70 |
| AMPK | interacts_with | gene | 0.70 |
| CTSB | interacts_with | gene | 0.70 |
| CTSD | interacts_with | gene | 0.70 |
| DNA | activates | gene | 0.70 |
| C9ORF72 | interacts_with | gene | 0.60 |
| LC3 | interacts_with | gene | 0.60 |
| P62 | interacts_with | gene | 0.60 |
| FUS | interacts_with | gene | 0.60 |
| UBIQUITIN | interacts_with | gene | 0.60 |
| SQSTM1 | interacts_with | gene | 0.60 |
| TRIM21 | interacts_with | gene | 0.60 |
| OPTN | interacts_with | gene | 0.60 |
| NEURODEGENERATIVE DISEASES | regulates | gene | 0.60 |
| ACTB | interacts_with | gene | 0.60 |
| ALS | interacts_with | gene | 0.60 |
| CALCOCO2 | interacts_with | gene | 0.60 |
| NBR1 | interacts_with | gene | 0.60 |
| ULK1 | interacts_with | gene | 0.60 |
| TAX1BP1 | interacts_with | gene | 0.60 |
| OPTINEURIN | interacts_with | gene | 0.60 |
| TOLLIP | interacts_with | gene | 0.60 |
| NDP52 | interacts_with | gene | 0.60 |
| MTOR | associated_with | gene | 0.60 |
| P62 | inhibits | gene | 0.60 |
| MYC | associated_with | gene | 0.60 |
| LC3 | regulates | gene | 0.60 |
| CANCER | associated_with | gene | 0.60 |
| ATG | associated_with | gene | 0.60 |
| SQSTM1 | regulates | gene | 0.60 |
| CSNK1A1 | associated_with | gene | 0.60 |
| APC | associated_with | gene | 0.60 |
| GSK3B | associated_with | gene | 0.60 |
| AMPK | associated_with | gene | 0.60 |
| GAPDH | associated_with | gene | 0.60 |
| RAB7A | associated_with | gene | 0.60 |
| CTNNB1 | associated_with | gene | 0.60 |
| MAP1LC3A | associated_with | gene | 0.60 |
| NIX | associated_with | gene | 0.60 |
| UBIQUITIN | associated_with | gene | 0.60 |
| BNIP3L | associated_with | gene | 0.60 |
| APOPTOSIS | associated_with | gene | 0.60 |
| PRKN | associated_with | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||