| Gene Symbol | FTL |
| Chromosome | 19q13.33 |
| Function | Fe²⁺ entry: Iron enters through 3-fold hydrophilic channels |
| Primary Expression | hippocampus, Hippocampus |
| Molecular Weight | 20 kDa |
| Exons | 4 |
| Pathways | Lipid Metabolism, Mitophagy, Autophagy, Oxidative Stress, Ferroptosis |
| UniProt ID | [P02792](https://www.uniprot.org/uniprot/P02792) |
| GeneCards | FTL |
| Human Protein Atlas | FTL |
| Heteropolymer formation | 12 FTL + 12 FTH1 subunits (optimal ratio) |
| Hollow shell | 12-nm diameter cavity for iron storage |
| Ferroxidase center | Catalytic site for iron oxidation (primarily in heavy chain) |
| Iron nucleation sites | Light chain facilitates iron core formation |
| Shell stability | Provides structural integrity for the iron core |
| Associated Diseases | Als, Dystonia, Leukemia, Ms, Neurodegeneration |
| Interactions | ACSL4, ALZHEIMER, ALZHEIMER'S DISEASE, APP, APP/PS1, ATP13A2 |
| SciDEX Hypotheses | Labile iron pool expansion amplifies genotype-spec |
| KG Connections | 118 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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