protein 876 words KG: GSDMD 2026-03-21
kind:proteinsection:proteinsstate:published
Contents

Gasdermin D Protein

🔬 Protein Info
Gene SymbolGSDMD
Functionis a gene encoding a key executor of pyroptotic cell death
Primary Expressionhippocampus, temporal lobe, cortex, Substantia Nigra, Ca1
Molecular Weight56 kDa
Amino Acids484 aa
PathwaysApoptosis, Ferroptosis, Inflammasome, Necroptosis, Oxidative Stress
GeneCardsGSDMD
Human Protein AtlasGSDMD
Associated DiseasesALS, Alzheimer, Alzheimer's disease, Cancer, Cardiovascular
Known Drugs/Compoundscurcumin, Qingqi Liangying Formula, Pterostilbene, natural products, XHP
InteractionsSCD1, HMGCR, TNF, MLKL, ACSL4, MYD88
KG Connections880 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Knowledge Graph (12 edges)

GSDMD phosphorylates MLKL
GSDMD associated_with IBA1
GSDMD associated_with NLRP3
GSDMD associated_with TREM2
GSDMD associated_with NEUROINFLAMMATION
GSDMD inhibits SCD1
GSDMD inhibits HMGCR
GSDMD inhibits TNF
GSDMD inhibits MLKL
GSDMD inhibits ACSL4