gene 1,200 words KG: SCD1 2026-03-24
kind:genesection:genesstate:published
Contents

SCD1 Gene

🧬 Gene Info
Gene SymbolSCD1
Chromosome10q24.31
Protein TypeEnzyme
Functionis an important component in the neurobiology of neurodegenerative diseases.
Primary Expressionmultiple cancers:
Molecular Weight60 kDa
Amino Acids360 aa
PathwaysAkt, Autophagy, Ferroptosis, Lipid Metabolism, Mtor
Ensembl IDENSG00000197294
GeneCardsSCD1
Human Protein AtlasSCD1
Enzyme typeMembrane-bound desaturase (EC 1.14.19.3)
LocationEndoplasmic reticulum membrane
SubstrateStearoyl-CoA (18:0), palmitoyl-CoA (16:0)
ProductOleoyl-CoA (18:1), palmitoleoyl-CoA (16:1)
Associated DiseasesALS, Cancer, Ferroptosis, Fibrosis, Neurodegeneration
Known Drugs/CompoundsSalidroside
InteractionsHMGCR, TNF, MLKL, ACSL4, GSDMD, FASN
KG Connections261 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (9)

ACSL4-Driven Ferroptotic Priming in Disease-Associated Micro
Score: 0.66
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.45
CYP46A1 Overexpression Gene Therapy
Score: 0.63
Senescence-Induced Lipid Peroxidation Spreading
Score: 0.53
Endothelial Glycocalyx Regeneration via Syndecan-1 Upregulat
Score: 0.50

Related Analyses (6)

Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived

Related Experiments (3)

Myricanol treatment in HFD-induced hyperlipidemic C57BL/6J m
validation · proposed · Score: 0.95
Myricanol-ACSL1 direct binding validation using CETSA and mo
exploratory · proposed · Score: 0.90
Multi-omics analysis of myricanol effects on gene expression
exploratory · proposed · Score: 0.88

See Also (12)

Apoptosis Pathway in Neurodegeneration
mechanism · KG edge: inhibits
Packard Center for ALS Research
institution · KG edge: inhibits
cd36
gene · KG edge: associated_with
BAX Gene
gene · KG edge: inhibits
ATF4 Gene
gene · KG edge: activates

Knowledge Graph (12 edges)

SCD1 inhibits HMGCR
SCD1 inhibits TNF
SCD1 inhibits MLKL
SCD1 inhibits ACSL4
SCD1 inhibits GSDMD
SCD1 inhibits FASN
SCD1 inhibits ALOX15
SCD1 inhibits MTOR
SCD1 activates AKT
SCD1 activates PTEN