| Gene Symbol | CYBB |
| Full Name | Cytochrome b-245, Beta Polypeptide |
| Chromosome | Xp21.1 |
| Function | The CYBB gene encodes the gp91^phox^ subunit (also called NOX2), which is the catalytic core of the NADPH oxidase (NOX2) enzyme complex. |
| Amino Acids | 570 aa |
| Pathways | COMPLEMENT, complement cascade |
| UniProt ID | P04839 |
| NCBI Gene ID | 1539 |
| Ensembl ID | ENSG00165195 |
| OMIM | 306500 |
| GeneCards | CYBB |
| Human Protein Atlas | CYBB |
| [Neurons](/entities/neurons) | Lower expression, but contributes to synaptic plasticity and redox signaling |
| [Astrocytes](/entities/astrocytes) | Involved in astrocyte-neuron communication |
| Associated Diseases | Aging, Als, Atrial Fibrillation, Chronic Granulomatous Disease, Depression |
| Interactions | AIF1, AMYLOID, APP, ATF4, C1QA, C1QB |
| KG Connections | 125 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
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