gene 838 words KG: APOC3 2026-03-24
kind:genesection:genesstate:published
Contents

APOC3 Gene

🧬 Gene Info
Gene SymbolAPOC3
Full NameApolipoprotein C-III
AliasesApoC-III, APOC3
Chromosome11q23.3
Functionis an important component in the neurobiology of neurodegenerative diseases.
Primary ExpressionHepatocytes in the liver (highest expression)
Molecular Weight8.8 kDa
Amino Acids79 aa
PathwaysCholesterol
NCBI Gene ID345
Ensembl IDENSG00000110245
GeneCardsAPOC3
Human Protein AtlasAPOC3
Therapy TypeExample
Antisense OligonucleotideVolanesorsen (ISIS 304801)
Associated DiseasesAging, Als, Atherosclerosis, Cardiovascular
InteractionsAPOA1, APOE, ABCA1, APOC1, ABCA2, APOC2
KG Connections100 knowledge graph edges
DatabasesGeneCardsUniProtHPASTRING

Knowledge Graph

Related Hypotheses (13)

SASP-Mediated Complement Cascade Amplification
Score: 0.70
CYP46A1 Overexpression Gene Therapy
Score: 0.63
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.59
Competitive APOE4 Domain Stabilization Peptides
Score: 0.56
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.54

Related Analyses (5)

Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (7)

Proposed experiment from debate on Synaptic pruning by micro
falsification · proposed · Score: 0.40
Proposed experiment from debate on Senolytics targeting p16/
falsification · proposed · Score: 0.40
Mechanism: Why Does Amyloid Removal Only Slow Decline 27%?
clinical · proposed · Score: 0.40
Experiment: Autoimmune Hypothesis Testing in AD
clinical · proposed · Score: 0.40
Mixed Pathology Effects on Parkinson's Disease Progression a
clinical · proposed · Score: 0.40

See Also (8)

Packard Center for ALS Research
institution · KG edge: associated_with
Alzheimer Indonesia
institution · KG edge: regulates
APP Gene Dosage Reduction Therapy for Down Syndrome
idea · KG edge: degrades
APOC2 Gene
gene · KG edge: activates
APOC1 Gene — Apolipoprotein C-I
gene · KG edge: activates

Knowledge Graph (12 edges)

APOC3 associated_with LDLR
APOC3 transports APOC2
APOC3 degrades APP
APOC3 degrades PSEN2
APOC3 activates APOA1
APOC3 degrades MAPT
APOC3 degrades SREBF1
APOC3 degrades NCSTN
APOC3 degrades PSEN1
APOC3 activates APOE