gene 891 words KG: AXIN2 2026-03-28
kind:genesection:genesstate:published
Contents

AXIN2 Gene

🧬 Gene Info
Gene SymbolAXIN2
Full NameAXIN2
Chromosome17q24.1
Protein TypeGene
Functionis a critical negative regulator of the Wnt/beta-catenin signaling pathway.
Primary Expressionneural stem cells (NSCs) in the adult subventricular zone (SVZ) and dentate gyrus subgranular zone (SGZ):
Molecular Weight88 kDa
Amino Acids778 aa
PathwaysWnt, Wnt signaling, Wnt pathway
UniProt IDQ9Y2T1
NCBI Gene ID8313
Ensembl IDENSG00000168646
GeneCardsAXIN2
Human Protein AtlasAXIN2
Associated DiseasesCancer, Carcinoma
Known Drugs/Compoundsrapamycin
InteractionsP62, MYC, MKI67, WIF1, AND, CCND1
KG Connections256 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (7)

CYP46A1 Overexpression Gene Therapy
Score: 0.63
APOE-Dependent Autophagy Restoration
Score: 0.61
RNA Granule Nucleation Site Modulation
Score: 0.48
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.45
Mitochondrial-Lysosomal Contact Site Engineering
Score: 0.43

Related Analyses (6)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Sleep disruption as cause and consequence of neurodegenerati
neurodegeneration · archived

See Also (8)

Packard Center for ALS Research
institution · KG edge: activates
AXIN1 Gene
gene · KG edge: regulates
ATF3 Gene
gene · KG edge: therapeutic_target
APC Gene
gene · KG edge: associated_with
ALDH1A1 Gene
gene · KG edge: therapeutic_target

Knowledge Graph (12 edges)

AXIN2 activates BECN1
AXIN2 activates CTNNB1
AXIN2 activates GAPDH
AXIN2 activates GSK3B
AXIN2 activates LAMP1
AXIN2 activates LC3
AXIN2 activates MTOR
AXIN2 activates RAB7A
AXIN2 activates SQSTM1
AXIN2 activates TCF4