gene 768 words KG: CCR5 2026-03-23
kind:genesection:genesstate:published
Contents

CCR5 Gene

🧬 Gene Info
Gene SymbolCCR5
Full NameCCR5
AliasesCCR5 chemokine receptor
Protein TypeGene
FunctionCCR5 is a seven-transmembrane G protein-coupled receptor that binds CCL3 (MIP-1α), CCL4 (MIP-1β), and CCL5 (RANTES).
Molecular Weight46 kDa
Amino Acids352 aa
PathwaysMAPK, PI3K
UniProt IDP51681
NCBI Gene IDSearch NCBI
GeneCardsCCR5
Human Protein AtlasCCR5
Associated DiseasesALS, Alzheimer, Inflammation, Neuroinflammation, Ptsd
InteractionsPI3K, APP, CCL5, FIS1, NLRP3, CCL4
KG Connections283 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (4)

CYP46A1 Overexpression Gene Therapy
Score: 0.63
APOE-Dependent Autophagy Restoration
Score: 0.61
Astrocyte-Mediated Neuronal Epigenetic Rescue
Score: 0.48
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.45

Related Analyses (4)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Epigenetic reprogramming in aging neurons
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (1)

Proposed experiment from debate on Synaptic pruning by micro
falsification · proposed · Score: 0.40

See Also (9)

Packard Center for ALS Research
institution · KG edge: activates
Alzheimer Indonesia
institution · KG edge: interacts_with
APP Gene Dosage Reduction Therapy for Down Syndrome
idea · KG edge: interacts_with
CCL3 Gene
gene · KG edge: activates
C3AR1 Gene
gene · KG edge: associated_with

Knowledge Graph (12 edges)

CCR5 activates PI3K
CCR5 interacts_with APP
CCR5 inhibits CCL5
CCR5 interacts_with FIS1
CCR5 activates NLRP3
CCR5 activates CCL4
CCR5 activates TAU
CCR5 therapeutic_target OVERVIEW
CCR5 therapeutic_target STING
CCR5 activates CCL5