| Gene Symbol | CD38 |
| Chromosome | 4p15.32 |
| Protein Type | Enzyme |
| Target Class | Enzyme |
| Function | cADPR acts as a potent second messenger that releases calcium from intracellular stores (endoplasmic reticulum) through ryanodine receptors[@guse2005]. |
| Mechanism of Action | Monoclonal antibody targeting or small molecule inhibitor of NAD+ consuming activity |
| Primary Expression | various tissues including brain cells (neurons, astrocytes, microglia) and plays important roles in neuro |
| Druggability | Medium (0.61) |
| Clinical Stage | Approved |
| Amino Acids | 301 aa |
| Pathways | Cerebrovascular, Circadian Rhythm, Differentiation, Immune Response, Mitochondrial Function |
| UniProt ID | H0Y950 |
| Ensembl ID | ENSG00000104419 |
| GeneCards | CD38 |
| Human Protein Atlas | CD38 |
| Associated Diseases | aging, Als, Alzheimer |
| Known Drugs/Compounds | CD38 inhibitors, nicotinamide, NICOTINAMIDE |
| Interactions | Actin, AGING, AND, APOE, APOPTOSIS, App |
| SciDEX Target | View Target Profile (8 clinical trials) |
| SciDEX Hypotheses | CD38 Inhibition for NAD+ Restoration and Microglia Astrocyte CD38-erk Mapk signaling controls mitocho CD38 Agonist Therapy for Alzheimer's Disease |
| KG Connections | 621 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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