gene

C1R

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about C1R: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

93Connections

0Hypotheses

0Analyses

50Outgoing

23Incoming

Summary

c1r

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🧬 Gene Info

Gene Symbol	C1R
Full Name	Complement Component 1, R Subcomponent
Chromosome	12p13.31
Protein Type	Protease
Function	is a critical component of the innate immune system, providing defense against pathogens and contributing to tissue homeostasis.
Primary Expression	the brain, where they participate in synaptic remodeling, neuroinflammation, and neurodegenerative processes
Pathways	Complement
UniProt ID	P09871
NCBI Gene ID	715
Ensembl ID	ENSG00000159403
OMIM	216950
GeneCards	C1R
Human Protein Atlas	C1R
Encoded Protein	C1r protease
Associated Diseases	Aging, Alzheimer, Senescence
Interactions	CD47, SIRPA, C1S, CLN5, CR1, PARP1
KG Connections	93 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: C1R — AlphaFold P09871 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    C1R["C1R"]
    Alzheimer["Alzheimer"]
    Als["Als"]
    Aging["Aging"]
    Senescence["Senescence"]
    SIRPA["SIRPA"]
    C1QC["C1QC"]
    C1S["C1S"]
    C1QA["C1QA"]
    AGING["AGING"]
    CD47["CD47"]
    Microglia["Microglia"]
    C1QB["C1QB"]
    ALZHEIMER["ALZHEIMER"]
    COMPLEMENT["COMPLEMENT"]
    GENES["GENES"]
    ITGAM["ITGAM"]
    MERTK["MERTK"]
    C1R -.-|"associated"| Alzheimer
    C1R -->|"regulates"| Als
    C1R -.-|"associated"| Aging
    C1R -.-|"associated"| Senescence
    C1R -->|"regulates"| SIRPA
    C1R -->|"regulates"| C1QC
    C1R -->|"regulates"| C1S
    C1R -->|"regulates"| C1QA
    C1R -.-|"associated"| AGING
    C1R -->|"regulates"| CD47
    C1R -->|"regulates"| Microglia
    C1QB -->|"regulates"| C1R
    ALZHEIMER -.-|"associated"| C1R
    COMPLEMENT -->|"regulates"| C1R
    C1R -.-|"discussed with"| C1S
    C1R -->|"activates"| CD47
    C1R -->|"activates"| GENES
    C1R -->|"regulates"| ITGAM
    C1R -->|"regulates"| MERTK
    C1R -->|"activates"| SIRPA
    style C1R fill:#006494,stroke:#333,color:#e0e0e0,stroke-width:2px

Outgoing (70)

Target	Relation	Type	Str
Alzheimer	associated_with	disease	0.65
Als	regulates	disease	0.65
Aging	associated_with	disease	0.65
Senescence	associated_with	disease	0.65
ALS	regulates	disease	0.65
SIRPA	regulates	gene	0.60
C1QC	regulates	gene	0.60
C1S	regulates	gene	0.60
C1QA	regulates	gene	0.60
CD47	regulates	gene	0.60
C1QB	regulates	gene	0.60
C3	regulates	gene	0.60
complement cascade	participates_in	pathway	0.60
C1S	biomarker_for	gene	0.60
C3	biomarker_for	gene	0.60
CHI3L1	biomarker_for	gene	0.60
CSF1R	biomarker_for	gene	0.60
GFAP	biomarker_for	gene	0.60
ITGAM	biomarker_for	gene	0.60
MAP2	biomarker_for	gene	0.60
MAPT	biomarker_for	gene	0.60
NLRP3	biomarker_for	gene	0.60
P2RY12	biomarker_for	gene	0.60
SNAP25	biomarker_for	gene	0.60
SYP	biomarker_for	gene	0.60
TMEM119	biomarker_for	gene	0.60
TREM2	biomarker_for	gene	0.60
C1S	interacts_with	gene	0.60
CLN5	interacts_with	gene	0.60
CR1	interacts_with	gene	0.60
PARP1	interacts_with	gene	0.60
SIGLEC9	interacts_with	gene	0.60
SIRPA	interacts_with	gene	0.60
TPP1	interacts_with	gene	0.60
VEGFB	interacts_with	gene	0.60
TMEM106B	associated_with	gene	0.60
TMEM106B	protects_against	gene	0.60
AGING	associated_with	gene	0.60
Microglia	regulates	cell_type	0.60
ALZHEIMER	associated_with	gene	0.60
SYNAPTIC PRUNING	associated_with	gene	0.60
AND	regulates	gene	0.60
COMPLEMENT GENES	associated_with	gene	0.60
ALZHEIMER'S DISEASE	associated_with	gene	0.60
NEURODEGENERATIVE DISORDERS	associated_with	gene	0.60
Complement	regulates	pathway	0.60
COMPLEMENT	regulates	gene	0.60
Complement System	regulates	pathway	0.60
microglia	expressed_in	cell_type	0.60
ubiquitin-proteasome	participates_in	pathway	0.60

Incoming (23)

Source	Relation	Type	Str
C1QB	regulates	gene	0.60
C1QC	regulates	gene	0.60
C1QA	regulates	gene	0.60
ITGAM	regulates	gene	0.60
CD47	regulates	gene	0.60
MERTK	regulates	gene	0.60
SIRPA	regulates	gene	0.60
C1S	regulates	gene	0.60
AIF1	biomarker_for	gene	0.60
C1QA	biomarker_for	gene	0.60
C1QB	biomarker_for	gene	0.60
C1QC	biomarker_for	gene	0.60
BIN1	associated_with	gene	0.60
BIN1	protects_against	gene	0.60
BIN1	interacts_with	gene	0.60
ALZHEIMER	associated_with	gene	0.60
COMPLEMENT	regulates	gene	0.60
AGING	associated_with	gene	0.60
GENES	regulates	gene	0.60
C1QA	co_discussed	gene	0.50
C1QB	co_discussed	gene	0.50
C1QC	co_discussed	protein	0.50
ALZHEIMER	regulates	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

C1R

Understanding Entity Pages

Summary

Wiki Pages (21)

C1R — Complement Component 1, R Subcomponent

CR1 Gene — Complement Component 1q Receptor

microglial-synaptic-pruning-dysregulation

Complement System in Neurodegeneration

Neuromyelitis Optica Spectrum Disorder (NMOSD)

Complement Activation in Corticobasal Degeneration

Complement System

Complement System in Neurodegeneration

Complement System Pathway in Neurodegeneration

C1QA Gene — Complement Component 1q A Chain

Synaptic Complement Inhibitor

C4B Gene

C1S Gene

C3 Protein (Complement Component 3)

C4A Gene

Reactive Astrogliosis

nrp2-protein

C2 (Complement Component 2)

Neuroimmune Interface Pathway