gene 871 words KG: FIS1 2026-03-24
kind:genesection:genesstate:published
Contents

FIS1 Gene

🧬 Gene Info
Gene SymbolFIS1
Full NameFission 1 Mitochondrial Outer Membrane Protein
AliaseshFis1, TTC4
Chromosome7q22.1
Protein TypeMitochondrial outer membrane protein
FunctionFis1 Gene plays an important role in the study of neurodegenerative diseases
Molecular Weight17 kDa
PathwaysApoptosis, Autophagy, Lysosomal Degradation, Mitochondrial Function, Mitophagy
GeneCardsFIS1
Human Protein AtlasFIS1
Protein ClassMitochondrial outer membrane protein
[DRP1](/genes/drp1) (DNM1L)Recruitment
MFFCo-receptor
PINK1Kinase
BAXPro-apoptotic
Associated DiseasesALS, Aging, Cardiomyopathy, Inflammation, Lymphoma
Known Drugs/CompoundsRAPAMYCIN
InteractionsLC3, DRP1, GBM, MFN2, CCR5, APP
KG Connections362 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (12)

Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.68
Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.67
Transcriptional Autophagy-Lysosome Coupling
Score: 0.66
CYP46A1 Overexpression Gene Therapy
Score: 0.63
Digital Twin-Guided Metabolic Reprogramming
Score: 0.61

Related Analyses (8)

Digital biomarkers and AI-driven early detection of neurodeg
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived

See Also (10)

Apoptosis Pathway in Neurodegeneration
mechanism · KG edge: associated_with
Packard Center for ALS Research
institution · KG edge: activates
APP Gene Dosage Reduction Therapy for Down Syndrome
idea · KG edge: interacts_with
BAX Gene
gene · KG edge: activates
ASC (PYCARD)
gene · KG edge: causes

Knowledge Graph (12 edges)

FIS1 activates MYD88
FIS1 activates NRF2
FIS1 activates PI3K
FIS1 activates PUMA
FIS1 activates SIGMAR1
FIS1 activates TAAR1
FIS1 activates TRAF6
FIS1 associated_with TRAF6
FIS1 associated_with CHOP
FIS1 associated_with NRF2