| Gene Symbol | SIGMAR1 |
| Full Name | Sigma Non-Opioid Intracellular Receptor 1 |
| Aliases | OPRS1, ERG28, Sigma-1R |
| Chromosome | 9p13.3 |
| Protein Type | Receptor |
| Function | Ligand binding: Small molecule agonists bind to the cytosolic domain, triggering conformational changes |
| Subcellular Localization | the endoplasmic reticulum (ER). The sigma-1 receptor plays critical roles in neuronal survival, calcium homeostasis, cel |
| Molecular Weight | 25.3 kDa |
| Amino Acids | 223 aa |
| Pathways | Blood-Brain Barrier, Toll-Like Receptor, apoptosis, inflammation |
| UniProt ID | Q9Y6D6 |
| NCBI Gene ID | 10280 |
| Ensembl ID | ENSG00000147955 |
| OMIM | 608978 |
| GeneCards | SIGMAR1 |
| Human Protein Atlas | SIGMAR1 |
| Associated Diseases | ALS, Inflammation, Lymphoma, Ms, frontotemporal dementia |
| Interactions | TLR4, MYD88, CHOP, BCL2, NRF2, PUMA |
| KG Connections | 188 knowledge graph edges |
| Databases | GeneCardsHPASTRING |