| Gene Symbol | IGF1R |
| Chromosome | 15q26.3 |
| Protein Type | Receptor |
| Function | Ligand (IGF1 or IGF2) binding to extracellular α-subunits |
| Amino Acids | 706 aa |
| Exons | 21 |
| Pathways | PI3K, MAPK |
| Ensembl ID | ENSG00000140443 |
| GeneCards | IGF1R |
| Human Protein Atlas | IGF1R |
| Exon 1-2 | 5' UTR and signal peptide |
| Exons 3-11 | α-subunit (extracellular ligand-binding domain) |
| Exons 12-21 | β-subunit (transmembrane and intracellular domains) |
| Alternative splicing | Produces variants with tissue-specific expression |
| Associated Diseases | AD, ALS, Alzheimer, Alzheimer's disease, DIABETES |
| Interactions | TNF, IGF1, BDNF, PDGFRB, PI3K, RELA |
| KG Connections | 340 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |