| Gene Symbol | IKBKE |
| Full Name | Inhibitor of Nuclear Factor Kappa-B Kinase Subunit Epsilon |
| Chromosome | 1q31.3 |
| Protein Type | Kinase |
| Function | IKBKE is a non-canonical IKK family member that phosphorylates IκB proteins and activates NF-κB signaling, but also has IκB-independent functions[@hemmings2007]: |
| Primary Expression | breast cancer[@hershko2004]
- Tumor Survival: Promotes tumor cell survival and proliferation
- Metastasis: Associated with metastatic potentia |
| Pathways | NF-κB, NF-κB signaling |
| UniProt ID | Q14164 |
| NCBI Gene ID | 9641 |
| Ensembl ID | ENSG00000105468 |
| OMIM | 605048 |
| GeneCards | IKBKE |
| Human Protein Atlas | IKBKE |
| Associated Diseases | Infection, Inflammation |
| Interactions | NDP52, TAX1BP1, P62, TBK1, OPTN, SQSTM1 |
| KG Connections | 98 knowledge graph edges |
| Databases | GeneCardsHPASTRING |