HNF4A

Understanding Entity Pages

This page aggregates everything SciDEX knows about HNF4A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

HNF4A encodes a nuclear receptor transcription factor critical for metabolic regulation, with emerging roles in Alzheimer's and Parkinson's disease pathogenesis.

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graph TD
    HNF4A["<b>HNF4A</b>"]
    Hepatitis{"Hepatitis"}
    HNF4A -->|"associated with"| Hepatitis
    Ms{"Ms"}
    HNF4A -->|"regulates"| Ms
    Diabetes{"Diabetes"}
    HNF4A -->|"regulates"| Diabetes
    Als{"Als"}
    HNF4A -->|"regulates"| Als
    IL6R["IL6R"]
    HNF4A -->|"activates"| IL6R
    STAT3["STAT3"]
    HNF4A -->|"regulates"| STAT3
    Cholesterol(["Cholesterol"])
    HNF4A -->|"associated with"| Cholesterol
    GAD2["GAD2"]
    HNF4A -->|"expressed in"| GAD2
    USH1C["USH1C"]
    HNF4A -->|"regulates"| USH1C
    neurodegeneration["neurodegeneration"]
    HNF4A -->|"implicated in"| neurodegeneration
    APOC2["APOC2"]
    APOC2 -->|"regulates"| HNF4A
    IL6["IL6"]
    IL6 -->|"activates"| HNF4A
    GENES["GENES"]
    GENES -->|"regulates"| HNF4A
    ABCD3["ABCD3"]
    ABCD3 -->|"regulates"| HNF4A
    style HNF4A fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0