gene 1,925 words KG: NLRP7 2026-03-28
kind:genesection:genesstate:published
Contents

NLRP7 — NLR Family Pyrin Domain Containing 7

🧬 Gene Info
Gene SymbolNLRP7
Full NameNLR Family Pyrin Domain Containing 7
AliasesNOD27, CLR19.9
Chromosome19q13.42
Protein TypeReceptor
Functionis a member of the NOD-like receptor (NLR) family of proteins that plays complex roles in innate immunity, inflammation, and cellular homeostasis.
Amino Acids956 aa
Exons10
PathwaysInflammasome, Innate Immunity, pyroptosis
UniProt IDQ8WX94
NCBI Gene ID199713
Ensembl IDENSG00000124313
OMIM609434
GeneCardsNLRP7
Human Protein AtlasNLRP7
Associated DiseasesAutoimmune
InteractionsNLRP12, CARD8, NLRP1, GAIN, NLRP3, NLRP2
KG Connections47 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (9)

Synthetic Biology BBB Endothelial Cell Reprogramming
Score: 0.57
Circadian-Synchronized LRP1 Pathway Activation
Score: 0.53
Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides
Score: 0.51
Dual-Domain Antibodies with Engineered Fc-FcRn Affinity Modu
Score: 0.57
Competitive APOE4 Domain Stabilization Peptides
Score: 0.56

Related Analyses (5)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · completed

Related Experiments (1)

Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40

See Also (15)

AIM2 Inflammasome Modulation Therapy for Neurodegenerat
idea · KG edge: interacts_with
NLRP3 Inflammasome Hypothesis in Parkinson's Disease
hypothesis · KG edge: activates
Autoimmune Hypothesis in Alzheimer's Disease
hypothesis · KG edge: activates
NLRP6 - NLR Family Pyrin Domain Containing 6
gene · KG edge: activates
NLRP2 — NLR Family Pyrin Domain Containing 2
gene · KG edge: activates

Knowledge Graph (12 edges)

NLRP7 activates NLRP12
NLRP7 activates CARD8
NLRP7 activates NLRP1
NLRP7 activates GAIN
NLRP7 activates NLRP3
NLRP7 activates NLRP2
NLRP7 activates NLRP6
NLRP7 interacts_with AIM2
NLRP7 associated_with CARD8
NLRP7 associated_with NLRP12