gene 700 words KG: NLRP1
Contents

NLRP1 Gene

🧬 Gene Info
Gene SymbolNLRP1
Full NameNLRP1 (NLR Family Pyrin Domain Containing 1)
Chromosome17p13.2
Protein TypeReceptor
Functionis an important component in the neurobiology of neurodegenerative diseases.
Primary Expressionvarious tissues with highest expression in:
Molecular Weight213 kDa
Amino Acids1839 aa
PathwaysInflammasome, Pyroptosis
UniProt IDQ9Y258
NCBI Gene ID22821
Ensembl IDENSG00000091592
GeneCardsNLRP1
Human Protein AtlasNLRP1
Associated DiseasesAls, Autoimmune, Cancer, Carcinoma, Cardiovascular
Known Drugs/Compoundsrapamycin
InteractionsAGING, AIFM1, AIM2, Akt, AKT, ALZHEIMER
KG Connections353 knowledge graph edges
DatabasesGeneCardsHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (12)

Synthetic Biology BBB Endothelial Cell Reprogramming
Score: 0.73
Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides
Score: 0.72
Circadian-Synchronized LRP1 Pathway Activation
Score: 0.71
LRP1-Dependent Tau Uptake Disruption
Score: 0.60
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82
Selective Acid Sphingomyelinase Modulation Therapy
Score: 0.78
CYP46A1 Overexpression Gene Therapy
Score: 0.77
Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.76
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69
TREM2 Conformational Stabilizers for Synaptic Discrimination
Score: 0.69
Microbial Inflammasome Priming Prevention
Score: 0.65
TREM2-mediated microglial tau clearance enhancement
Score: 0.62

Related Analyses (6)

Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · completed
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived

Related Experiments (3)

Anti-Tau Immunotherapy Dosing Optimization
clinical · proposed · Score: 0.40
Tau PET Pattern as Therapeutic Response Predictor in 4R-Tauo
clinical · proposed · Score: 0.40
Tau Propagation Causality Test — Does Tau Spread Drive Neuro
clinical · proposed · Score: 0.40

See Also (15)

Alzheimer Indonesia
institution · KG edge: expressed_in
AIFM1 Gene
gene · KG edge: activates
BAX Gene
gene · KG edge: activates
Apoptosis Pathway in Neurodegeneration
mechanism · KG edge: expressed_in
AIM2 Inflammasome Modulation Therapy for Neurodegenerat
idea · KG edge: associated_with

Knowledge Graph (12 edges)

NLRP1 associated_with DEPRESSION
NLRP1 activates BAX
BAX activates NLRP1
NLRP1 associated_with Major depressive disorder
NLRP1 regulates autophagy
NLRP1 activates pro-inflammatory cytokines
NLRP1 associated_with major depressive disorder
chronic social defeat stress activates NLRP1
NLRP1 expressed_in P62
NLRP1 activates SQSTM1

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