gene 721 words KG: CARD8 2026-03-29
kind:genesection:genesstate:published
Contents

CARD8 - Caspase Recruitment Domain Family Member 8

🧬 Gene Info
Gene SymbolCARD8
Full NameCaspase Recruitment Domain Family Member 8
Chromosome19q13.33
Functionis a critical regulator of the innate immune inflammasome complex.
Primary Expressionneurons, astrocytes, and microglia, where it participates in n
Amino Acids541 aa
PathwaysPyroptosis
UniProt IDQ9Y2585
NCBI Gene ID8912
Ensembl IDENSG00000105464
OMIM609508
GeneCardsCARD8
Human Protein AtlasCARD8
Associated DiseasesALS, Autoimmune, Cancer, Cardiovascular, Inflammation
InteractionsNLRP2, NLRP6, NLRP7, NLRP1, NLRP12, NLRP3
KG Connections90 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (9)

Synthetic Biology BBB Endothelial Cell Reprogramming
Score: 0.57
Circadian-Synchronized LRP1 Pathway Activation
Score: 0.53
Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides
Score: 0.51
Dual-Domain Antibodies with Engineered Fc-FcRn Affinity Modu
Score: 0.57
Competitive APOE4 Domain Stabilization Peptides
Score: 0.56

Related Analyses (5)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · completed

Related Experiments (2)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40
Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40

See Also (15)

Caspase-1 Protein
redirect · KG edge: associated_with
Packard Center for ALS Research
institution · KG edge: associated_with
AIM2 Inflammasome Modulation Therapy for Neurodegenerat
idea · KG edge: associated_with
Autoimmune Hypothesis in Alzheimer's Disease
hypothesis · KG edge: activates
Wnt/β-Catenin Signaling Pathway in Neurodegeneration
mechanism · Pages share 3 hypotheses

Knowledge Graph (12 edges)

CARD8 associated_with NLRP1
CARD8 associated_with AIM2
CARD8 associated_with NLRP3
CARD8 activates NLRP2
CARD8 activates NLRP6
CARD8 activates NLRP7
CARD8 activates NLRP1
CARD8 activates NLRP12
CARD8 activates NLRP3
CARD8 associated_with GSDMD