gene 639 words KG: NRXN3 2026-03-24
kind:genesection:genesstate:published
Contents

NRXN3 Gene

🧬 Gene Info
Gene SymbolNRXN3
Chromosome14q31.1.
Functionis an important component in the neurobiology of neurodegenerative diseases.
Primary Expressioncerebral cortex (layer 2/3 pyramidal neurons), hippocampus (CA1-CA3, dentate gyrus), striatum (
Molecular Weight180 kDa
Exons24
PathwaysOxidative Stress, Sod1
GeneCardsNRXN3
Human Protein AtlasNRXN3
Associated DiseasesALS, Alzheimer
InteractionsPDHA1, BDNF, PRKAA1, SOD1, NLGN2, CYCS
KG Connections79 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (6)

Trans-Synaptic Adhesion Molecule Modulation
Score: 0.34
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.68
CYP46A1 Overexpression Gene Therapy
Score: 0.63
AMPK hypersensitivity in astrocytes creates enhanced mitocho
Score: 0.57
Near-infrared light therapy stimulates COX4-dependent mitoch
Score: 0.51

Related Analyses (4)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (15)

CREB-independent Neuronal Survival Pathways
mechanism · KG edge: protects_against
Packard Center for ALS Research
institution · KG edge: protects_against
Alzheimer Indonesia
institution · KG edge: regulates
NRXN2 Gene
gene · KG edge: interacts_with
NRXN1 Gene
gene · KG edge: regulates

Knowledge Graph (12 edges)

NRXN3 inhibits PDHA1
NRXN3 inhibits BDNF
NRXN3 inhibits PRKAA1
NRXN3 protects_against SOD2
NRXN3 inhibits SOD1
NRXN3 inhibits NLGN2
NRXN3 protects_against PSD95
NRXN3 inhibits CYCS
NRXN3 inhibits CAT
NRXN3 inhibits SLC2A2