gene 566 words KG: NPTX1 2026-03-21
kind:genesection:genesstate:published
Contents

NPTX1 — Neuronal Pentraxin 1

🧬 Gene Info
Gene SymbolNPTX1
Full NameNeuronal Pentraxin 1
FunctionNeuronal Pentraxin 1 (NPTX1) is a member of the pentraxin family of proteins, which are characterized by their ability to bind to phosphatidylserine and apoptotic cells.
Molecular Weight47 kDa
Amino Acids430 aa
Pathwaysoxidative stress response
Ensembl IDENSG00000143157
GeneCardsNPTX1
Human Protein AtlasNPTX1
Associated DiseasesInflammation, Neuroinflammation
InteractionsSERPINA3, CTSB, CTSD, PDGFRB, SYNAPSE, CHI3L1
KG Connections111 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (9)

Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.68
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.59
Competitive APOE4 Domain Stabilization Peptides
Score: 0.56
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.54
Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.53

Related Analyses (3)

SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
Metabolic reprogramming in neurodegenerative disease
neurodegeneration · completed

Related Experiments (3)

Epigenetic Dysregulation Validation in Parkinson's Disease
clinical · proposed · Score: 0.40
Multiscale Computational Modeling of Protein Aggregation Kin
validation · proposed · Score: 0.40
Non-Motor Symptom Progression in Parkinson's Disease — Mecha
clinical · proposed · Score: 0.40

See Also (12)

Packard Center for ALS Research
institution · KG edge: biomarker_for
Alzheimer Indonesia
institution · KG edge: biomarker_for
APOE contributes to Alzheimer's disease by regulating b
hypothesis · KG edge: biomarker_for
IL4 Gene
gene · KG edge: biomarker_for
FGF2 — Fibroblast Growth Factor 2
gene · KG edge: biomarker_for

Knowledge Graph (12 edges)

NPTX1 associated_with CHIT1
NPTX1 biomarker_for MDH1
NPTX1 associated_with PDGFRB
NPTX1 biomarker_for SQSTM1
NPTX1 biomarker_for BDNF
NPTX1 biomarker_for APOE
NPTX1 biomarker_for NEFL
NPTX1 associated_with CHI3L1
NPTX1 associated_with VEGFA
NPTX1 biomarker_for GFAP