gene 1,998 words KG: NTS
Contents

NTS — Neurotensin

🧬 Gene Info
Gene SymbolNTS
Full NameNeurotensin
Chromosome12q13.13
FunctionThe peptide is derived from a 169-amino acid precursor that also produces the related hexapeptide neuromedin N.
Primary Expressionthe substantia nigra, particularly in the pars reticulata
Amino Acids13 aa
PathwaysMAPK, MAPK pathway
UniProt IDP30990
NCBI Gene ID4902
Ensembl IDENSG00000133636
OMIM162650
GeneCardsNTS
Human Protein AtlasNTS
Associated DiseasesALS, Migraine, stroke
InteractionsAND, ANXA1, ARC, AUTOPHAGY, BDNF, BIP
KG Connections170 knowledge graph edges
DatabasesGeneCardsHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (13)

TREM2-mediated microglial tau clearance enhancement
Score: 0.62
LRP1-Dependent Tau Uptake Disruption
Score: 0.60
VCP-Mediated Autophagy Enhancement
Score: 0.59
Extracellular Vesicle Biogenesis Modulation
Score: 0.58
Synaptic Vesicle Tau Capture Inhibition
Score: 0.58
HSP90-Tau Disaggregation Complex Enhancement
Score: 0.57
Trans-Synaptic Adhesion Molecule Modulation
Score: 0.54
Enhancing Vagal Cholinergic Signaling to Restore Gut-Brain A
Score: 0.67
Optogenetic Microglial Deactivation via Engineered Inhibitor
Score: 0.66
Synaptic Phosphatidylserine Masking via Annexin A1 Mimetics
Score: 0.62
Vagal Afferent Microbial Signal Modulation
Score: 0.62
Fractalkine Axis Amplification via CX3CR1 Positive Allosteri
Score: 0.56
Gut Barrier Permeability-α-Synuclein Axis Modulation
Score: 0.53

Related Analyses (4)

Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived
Synaptic pruning by microglia in early AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (5)

Anti-Tau Antibody vs ASO/Gene Therapy — Comparative Efficacy
validation · proposed · Score: 0.40
cGAS-STING Pathway Validation Study in Parkinson's Disease
clinical · proposed · Score: 0.40
Non-Motor Symptom Progression in Parkinson's Disease — Mecha
clinical · proposed · Score: 0.40
Spinocerebellar Ataxia (SCA) Disease-Modifying Therapy Devel
validation · proposed · Score: 0.40
Tau ASO Therapy
validation · proposed · Score: 0.40

See Also (9)

ARC-IM Adaptive Neurostimulation for PD
clinical · KG edge: interacts_with
Apoptosis in Neurodegeneration
entity · KG edge: expressed_in
Autophagy Enhancement Drug Screening for Neurodegenerat
experiment · KG edge: activates
ANXA1 — Annexin A1
gene · KG edge: activates
BDNF Gene
gene · KG edge: activates

Knowledge Graph (12 edges)

ANXA1 protects_against NTS
NBR1 activates NTS
TNF inhibits NTS
CRH regulates NTS
POMC regulates NTS
NTS interacts_with ARC
NTS regulates NPY
NR4A2 biomarker_for NTS
CXCL2 biomarker_for NTS
CSF2 biomarker_for NTS

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