| Gene Symbol | P75NTR |
| Chromosome | 17q21.33 |
| Protein Family | TNF receptor superfamily (TNFRSF16) |
| Protein Type | Receptor |
| Function | is a member of the tumor necrosis factor receptor superfamily that serves as a key modulator of neurotrophin signaling. |
| Molecular Weight | 75 kDa |
| Amino Acids | 427 aa |
| Exons | 6 |
| Pathways | NF-κB |
| GeneCards | P75NTR |
| Human Protein Atlas | P75NTR |
| Pathway | Outcome |
| NF-κB | Survival or death depending on context |
| JNK | Pro-apoptotic stress kinase cascade |
| PI3K/Akt | Pro-survival signaling with Trk |
| Associated Diseases | ALS, Alzheimer, Cancer, Depression, Glioblastoma |
| Interactions | TNF, SIRT1, NRF2, AKT, RHOA, TNF-Α |
| KG Connections | 148 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |