gene 1,782 words KG: PON1
Contents

PON1 — Paraoxonase 1

🧬 Gene Info
Gene SymbolPON1
Chromosome7q21.3.
Protein TypeEnzyme
Functionis a calcium-dependent esterase enzyme encoded by the PON1 gene on chromosome 7q21.
Primary Expressionthe liver (hepatocytes) and secreted into plasma
Molecular Weight43 kDa
Amino Acids354 aa
UniProt IDP27169
NCBI Gene ID5444
Ensembl IDENSG00000005421
OMIM168000
GeneCardsPON1
Human Protein AtlasPON1
Gene NameParaoxonase 1
Encoded ProteinParaoxonase 1
Associated DiseasesAls, Atherosclerosis, Breast Cancer, Cancer, Depression, Inflammation
InteractionsCLU
KG Connections46 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (12)

Digital Twin-Guided Metabolic Reprogramming
Score: 0.61
Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides
Score: 0.51
Circadian-Gated Maresin Biosynthesis Amplification
Score: 0.47
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.59
Competitive APOE4 Domain Stabilization Peptides
Score: 0.56

Related Analyses (1)

Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (8)

Packard Center for ALS Research
institution · KG edge: associated_with
APOE contributes to Alzheimer's disease by regulating b
hypothesis · KG edge: associated_with
MMP3 Gene
gene · KG edge: associated_with
IGF1 Gene
gene · KG edge: therapeutic_target
ESR1 — Estrogen Receptor Alpha
gene · KG edge: therapeutic_target

Knowledge Graph (12 edges)

PON1 therapeutic_target IGF1
PON1 therapeutic_target SERPINE1
PON1 therapeutic_target APOA1
PON1 therapeutic_target PPARGC1A
PON1 therapeutic_target ESR1
PON1 associated_with APOE
PON1 associated_with ACE
PON1 associated_with PTGS2
PON1 therapeutic_target PER
PON1 therapeutic_target Carcinoma