disease

Synucleinopathy

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about Synucleinopathy: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

482Connections

0Hypotheses

1Analyses

44Outgoing

50Incoming

No summary available yet. View on Wiki →

Disease Info

Associated Genes	DNA, STING, CGAS, SNCA, GBA, SCARB2, SNCA-AS1, INPP5F
KG Connections	212 knowledge graph edges
Databases	OMIM Orphanet ClinicalTrials PubMed

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    Synucleinopathy["Synucleinopathy"] -->|"activates"| Parkinson["Parkinson"]
    Synucleinopathy["Synucleinopathy"] -->|"causes"| Neurodegeneration["Neurodegeneration"]
    Synucleinopathy["Synucleinopathy"] -->|"activates"| Autophagy["Autophagy"]
    Synucleinopathy["Synucleinopathy"] -->|"activates"| Phagocytosis["Phagocytosis"]
    Synucleinopathy["Synucleinopathy"] -->|"activates"| Immune_Response["Immune Response"]
    Synucleinopathy["Synucleinopathy"] -->|"activates"| Stem_Cell["Stem Cell"]
    PARKINSON_S_DISEASE["PARKINSON'S DISEASE"] -->|"activates"| Synucleinopathy["Synucleinopathy"]
    Parkinson_1["Parkinson"] -->|"associated"| Synucleinopathy["Synucleinopathy"]
    NEURODEGENERATIVE_DISEASES["NEURODEGENERATIVE DISEASES"] -->|"activates"| Synucleinopathy["Synucleinopathy"]
    NEUROINFLAMMATION["NEUROINFLAMMATION"] -->|"activates"| Synucleinopathy["Synucleinopathy"]
    style Synucleinopathy fill:#ef5350,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (217)

Target	Relation	Type	Str
Parkinson	activates	disease	0.65
Neurodegeneration	causes	disease	0.65
Autophagy	activates	pathway	0.60
Phagocytosis	activates	pathway	0.60
Immune Response	activates	pathway	0.60
Stem Cell	activates	pathway	0.60
Mitophagy	inhibits	pathway	0.60
Blood-Brain Barrier	therapeutic_target	pathway	0.60
Nf-Κb	therapeutic_target	pathway	0.60
Immune Response	therapeutic_target	pathway	0.60
Apoptosis	activates	pathway	0.60
Autophagy	associated_with	pathway	0.60
Senescence	associated_with	disease	0.55
Neuroinflammation	associated_with	disease	0.55
Inflammation	associated_with	disease	0.55
Parkinson	associated_with	disease	0.55
Ms	associated_with	disease	0.55
Amyloid	activates	pathway	0.55
Chaperone	activates	pathway	0.55
Alpha-Synuclein	inhibits	pathway	0.55
Parkinson	inhibits	disease	0.55
Als	causes	disease	0.55
Neurodegeneration	associated_with	disease	0.55
Dementia	associated_with	disease	0.55
Neurodegeneration	therapeutic_target	disease	0.55
Neurodegeneration	activates	disease	0.55
Nf-Κb	inhibits	pathway	0.55
Blood-Brain Barrier	activates	pathway	0.55
Nf-Κb	activates	pathway	0.55
Alpha-Synuclein	phosphorylates	pathway	0.55
Protein Aggregation	associated_with	pathway	0.55
Oxidative Stress	associated_with	pathway	0.55
Amyloid	associated_with	pathway	0.55
Substantia Nigra	associated_with	brain_region	0.50
Striatum	associated_with	brain_region	0.50
SYNUCLEIN	inhibits	concept	0.50
SYNUCLEIN	associated_with	concept	0.50
α-SYNUCLEIN	associated_with	concept	0.50
SYNUCLEIN	activates	concept	0.50
α-SYNUCLEIN	activates	concept	0.50
ENDOTHELIAL	associated_with	concept	0.50
NEURONS	inhibits	concept	0.50
DOPAMINERGIC	inhibits	concept	0.50
DOPAMINERGIC NEURONS	inhibits	concept	0.50

Incoming (265)

Source	Relation	Type	Str
SNCA	contributes_to	gene	0.90
PARKINSON'S DISEASE	activates	gene	0.85
Parkinson	associated_with	disease	0.75
NEURODEGENERATIVE DISEASES	activates	gene	0.75
NEUROINFLAMMATION	activates	gene	0.75
NEURODEGENERATION	activates	gene	0.75
SYNUCLEINOPATHY	therapeutic_target	gene	0.75
SYNUCLEINOPATHY	activates	gene	0.75
PARKINSON	activates	gene	0.75
ALPHA-SYNUCLEIN	activates	gene	0.75
NEURODEGENERATION	causes	gene	0.75
PARKINSON'S DISEASE	associated_with	gene	0.75
PARKINSON	associated_with	gene	0.75
SYNUCLEINOPATHY	associated_with	gene	0.75
BMAL1	inhibits	gene	0.65
BAG3	activates	gene	0.65
CLOCK	activates	gene	0.65
TFR1	activates	gene	0.65
GPX4	activates	gene	0.65
MLKL	activates	gene	0.65
RIPK3	activates	gene	0.65
GENES	activates	gene	0.65
DNA	associated_with	gene	0.65
STING	associated_with	gene	0.65
CGAS	associated_with	gene	0.65
CTSD	activates	gene	0.65
SNCA	activates	gene	0.65
TNF	therapeutic_target	gene	0.65
GAN	therapeutic_target	gene	0.65
SNCA	associated_with	gene	0.65
GBA	associated_with	gene	0.65
SCARB2	associated_with	gene	0.65
SNCA-AS1	associated_with	gene	0.65
INPP5F	associated_with	gene	0.65
TMEM175	associated_with	gene	0.65
AUTOPHAGY	activates	gene	0.65
NURR1	activates	gene	0.65
GFAP	activates	gene	0.65
PHAGOCYTOSIS	activates	gene	0.65
AMYLOID	activates	gene	0.65
ASTROCYTES	activates	gene	0.65
TAU PATHOLOGY	activates	gene	0.65
TAUOPATHY	inhibits	gene	0.65
SYNUCLEINOPATHY	inhibits	gene	0.65
ASTROCYTE	activates	gene	0.65
ALPHA-SYNUCLEIN	inhibits	gene	0.65
TAU	inhibits	gene	0.65
AMYLOID-BETA	activates	gene	0.65
NEURODEGENERATION	therapeutic_target	gene	0.65
NEURODEGENERATIVE DISEASES	therapeutic_target	gene	0.65

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

How does PSEN2 mechanistically regulate α-synuclein expression and pathology in

neurodegeneration | 2026-04-13 | 0 hypotheses

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Synucleinopathy

Understanding Entity Pages

Wiki Pages (21)