| Gene Symbol | SIRT3 |
| Full Name | Sirtuin 3 |
| Aliases | Page for SIRT3, Page for SIRT3 Protein |
| Chromosome | 11p15.5 |
| Protein Type | Enzyme |
| Target Class | Enzyme |
| Function | SIRT3 is the primary mitochondrial deacetylase, regulating key metabolic enzymes and proteins involved in |
| Mechanism of Action | Enzyme activation — enhancing SIRT3 deacetylase activity restores mitochondrial protein function and reduces oxidative stress |
| Subcellular Localization | mitochondria. It plays a critical role in regulating mitochondrial function, metabolism, and cellular stress responses |
| Druggability | Medium (0.61) |
| Clinical Stage | Phase II |
| Molecular Weight | 44 kDa |
| Amino Acids | 25 aa |
| Pathways | Akt, Angiogenesis, Apoptosis, Autophagy, Mtor |
| UniProt ID | Q9NWU1 |
| NCBI Gene ID | 23410 |
| Ensembl ID | ENSG00000142092 |
| OMIM | 604479 |
| GeneCards | SIRT3 |
| Human Protein Atlas | SIRT3 |
| Associated Diseases | aging, ALS, Alzheimer, alzheimer_s_disease |
| Known Drugs/Compounds | Aloe-emodin, Epigallocatechin gallate, Epigallocatechin Gallate, Honokiol, METFORMIN, Nad |
| Interactions | ACOX1, Actin, Adiponectin, ADIPOQ, AGING, AKT |
| SciDEX Target | View Target Profile (8 clinical trials) |
| SciDEX Hypotheses | SIRT3-Mediated Mitochondrial Deacetylation Failure Mitochondrial-Nuclear Epigenetic Cross-Talk Restor SIRT3 gates microglial surveillance versus primed |
| KG Connections | 1150 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
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