gene 2,543 words KG: SMAD6 2026-03-27
kind:genesection:genesstate:published
Contents

SMAD6 — SMAD Family Member 6

🧬 Gene Info
Gene SymbolSMAD6
Full NameSMAD family member 6
Chromosome15q22.21
Protein TypeInhibitory SMAD, transcription regulator
Functionis a gene located on chromosome 15q22.
Primary ExpressionCortex, Hippocampus, Heart, Lung
PathwaysTGF-β
UniProt IDO43541
NCBI Gene ID4092
Ensembl IDENSG00000168487
OMIM607929
GeneCardsSMAD6
Human Protein AtlasSMAD6
Protein ClassInhibitory SMAD, transcription regulator
Molecular FunctionBMP signaling inhibitor, TGF-beta signaling modulator, transcription cofactor
Associated DiseasesAls, Alzheimer, Autoimmune, Cancer, Carcinoma, Diabetes
InteractionsTET2
KG Connections43 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (4)

GFAP-Positive Reactive Astrocyte Subtype Delineation
Score: 0.52
Fractalkine Axis Amplification via CX3CR1 Positive Allosteri
Score: 0.50
Astrocyte-Mediated Neuronal Epigenetic Rescue
Score: 0.48
Optogenetic Microglial Deactivation via Engineered Inhibitor
Score: 0.38

Related Analyses (2)

Synaptic pruning by microglia in early AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (2)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40
Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40

See Also (15)

Packard Center for ALS Research
institution · KG edge: associated_with
Alzheimer Indonesia
institution · KG edge: associated_with
CX3CR1 Modulation Therapy for Neurodegeneration
idea · KG edge: associated_with
Autoimmune Hypothesis in Alzheimer's Disease
hypothesis · KG edge: associated_with
RORA — RAR Related Orphan Receptor A
gene · KG edge: associated_with

Knowledge Graph (12 edges)

SMAD6 associated_with FOXP2
SMAD6 associated_with GATA3
SMAD6 associated_with ATF6
SMAD6 associated_with MAF
SMAD6 interacts_with TET2
SMAD6 regulates TET2
SMAD6 associated_with TET2
SMAD6 associated_with Hepatitis
SMAD6 associated_with Glioblastoma
SMAD6 associated_with Alzheimer