gene 740 words KG: TLR1
Contents

TLR1 Gene

🧬 Gene Info
Gene SymbolTLR1
Full NameToll-Like Receptor 1
Chromosome4p14
Protein TypeReceptor
Primary Expressionmicroglia and contributes to neuroinflammatory processes in neurodegenerative diseases
Molecular Weight90 kDa
Amino Acids799 aa
PathwaysNF-κB, MAPK, MAPK pathway
UniProt IDQ9Y5S2
NCBI Gene ID7099
Ensembl IDENSG00000174125
OMIM601194
GeneCardsTLR1
Human Protein AtlasTLR1
Pattern recognition receptorDetects microbial-associated molecular patterns (MAMPs)
Associated Diseasesneurodegeneration
InteractionsCMPK2, CYTOKINES, ECSIT, IBA1, IL6, INFLAMMATION
KG Connections48 knowledge graph edges
DatabasesGeneCardsHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (2)

CYP46A1 Overexpression Gene Therapy
Score: 0.77
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69

Related Analyses (3)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (15)

TLR4 (Redirect)
redirect · KG edge: activates
ECSIT — Evolutionarily Conserved Signaling Intermediate
gene · KG edge: activates
HMGB1 — High Mobility Group Box 1
gene · KG edge: expressed_in
IKBKB Gene
gene · KG edge: expressed_in
IKBKG Gene
gene · KG edge: expressed_in

Knowledge Graph (12 edges)

TLR4 expressed_in TLR1
IL1B expressed_in TLR1
TLR3 expressed_in TLR1
RAGE expressed_in TLR1
IRAK2 expressed_in TLR1
IL10 expressed_in TLR1
IRAK1 expressed_in TLR1
IKBKG expressed_in TLR1
TLR2 expressed_in TLR1
TLR1 expressed_in HMGB1

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