| Gene Symbol | IRAK1 |
| Protein Family | IL-1 receptor-associated kinases |
| Protein Type | Serine/Threonine Kinase |
| Function | IRAK1 is a serine/threonine kinase recruited to activated TLR/IL-1R complexes via MyD88. |
| Molecular Weight | 77 kDa |
| Amino Acids | 712 aa |
| Pathways | NF-κB, MAPK pathway, MAPK, NF-κB pathway |
| UniProt ID | [P51617](https://www.uniprot.org/uniprot/P51617) |
| GeneCards | IRAK1 |
| Human Protein Atlas | IRAK1 |
| N-terminal Death Domain (DD) | Mediates interactions with MyD88 and other adaptor proteins |
| ProST domain | Proline-rich region involved in protein-protein interactions |
| Kinase Domain (KD) | Catalytic domain with serine/threonine kinase activity |
| C-terminal domain | Regulatory region controlling kinase activity |
| Phosphorylation | Autophosphorylation at multiple serine/threonine residues (Thr387, Ser376) activates the kinase |
| Associated Diseases | neurodegeneration |
| Interactions | AKT, ASC, ASK1, ATF3, ATG5, CCR2 |
| KG Connections | 76 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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