NCL

Understanding Entity Pages

This page aggregates everything SciDEX knows about NCL: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

NCL is a gene implicated in neurodegeneration research. Key relationships include: involved in, activates, regulates. Associated with Als, Alzheimer's Disease, Autoimmune Diseases. Connected to 32 entities in the SciDEX knowledge graph.

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graph TD
    NCL["NCL (Nucleolin)"]
    
    %% Core cellular processes
    NCL -->|"regulates"| RNA_Transcription["RNA Transcription"]
    NCL -->|"processes"| rRNA_Processing["rRNA Processing"]
    NCL -->|"stabilizes"| mRNA_Stabilization["mRNA Stabilization"]
    NCL -->|"facilitates"| DNA_Replication["DNA Replication"]
    NCL -->|"remodels"| Chromatin_Remodeling["Chromatin Remodeling"]
    
    %% Gene regulation
    NCL -->|"regulates"| HIPPO["HIPPO Pathway"]
    NCL -->|"controls"| MicroRNA["MicroRNA Processing"]
    NCL -->|"activates"| ERK["ERK Signaling"]
    
    %% Cell fate processes
    RNA_Transcription -->|"promotes"| Cell_Proliferation["Cell Proliferation"]
    NCL -->|"upregulates"| Cell_Proliferation
    NCL -->|"modulates"| Apoptosis["Apoptosis"]
    Cell_Proliferation -->|"leads to"| Cytokinesis["Cytokinesis"]
    
    %% Neurodegeneration context
    NCL -->|"associated with"| Alzheimers["Alzheimer's Disease"]
    NCL -->|"therapeutic target"| ALS["ALS"]
    
    %% Pathological outcomes
    ERK -->|"promotes"| Invasion["Cell Invasion"]
    NCL -->|"activates"| Cancer["Cancer/Carcinoma"]
    Cell_Proliferation -->|"contributes to"| Cancer
    
    %% Styling
    style NCL fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px
    style rRNA_Processing fill:#1b5e20,stroke:#2e7d32
    style mRNA_Stabilization fill:#1b5e20,stroke:#2e7d32
    style HIPPO fill:#4a1a6b,stroke:#7b1fa2
    style ERK fill:#4a1a6b,stroke:#7b1fa2
    style Alzheimers fill:#7d4200,stroke:#ef6c00
    style ALS fill:#7d4200,stroke:#ef6c00
    style Cancer fill:#ef5350,stroke:#c62828
    style Apoptosis fill:#1b5e20,stroke:#2e7d32