gene 2,886 words KG: VPS35
Contents

VPS35 — Vacuolar Protein Sorting 35 Homolog

🧬 Gene Info
Gene SymbolVPS35
Full NameVacuolar Protein Sorting 35 Homolog
AliasesVacuolar Protein Sorting 35
Protein TypeProtein
FunctionCargo Recognition: Binds to transmembrane cargo proteins containing cytoplasmic sorting motifs
Molecular Weight91.6 kDa
Amino Acids796 aa
PathwaysWnt
UniProt IDSearch UniProt
GeneCardsVPS35
Human Protein AtlasVPS35
Associated DiseasesAls, Alzheimer, Alzheimer's disease, Amyotrophic Lateral Sclerosis
InteractionsABCA1, ABCA7, AD, AMYLOID, AND, APP
SciDEX HypothesesVPS35 retromer activation prevents endosomal tau t
VPS35 Retromer Dysfunction Creates a GCase Traffic
KG Connections430 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (24)

Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79
Competitive APOE4 Domain Stabilization Peptides
Score: 0.78
Selective Acid Sphingomyelinase Modulation Therapy
Score: 0.78
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76
Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.76
Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.76
APOE Isoform Expression Across Glial Subtypes
Score: 0.74
APOE-TREM2 Interaction Modulation
Score: 0.74
SIRT3-Mediated Mitochondrial Deacetylation Failure with PINK
Score: 0.74
Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.72
Lysosomal Enzyme Trafficking Correction
Score: 0.71
Extracellular Matrix Stiffness Modulation
Score: 0.69
Lysosomal Positioning Dynamics Modulation
Score: 0.69
TREM2 Conformational Stabilizers for Synaptic Discrimination
Score: 0.69
Optogenetic Microglial Deactivation via Engineered Inhibitor
Score: 0.66
Multi-Modal CRISPR Platform for Simultaneous Editing and Mon
Score: 0.63
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62
Pharmacological Enhancement of APOE4 Glycosylation
Score: 0.62
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Related Analyses (11)

Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed

See Also (14)

ABCA7 (Redirect)
redirect · KG edge: associated_with
Apoptosis in Neurodegeneration
entity · KG edge: regulates
Amyloid-Related Imaging Abnormalities (ARIA)
entity · KG edge: associated_with
c9orf72-als-ftd-phenotype-mechanism
general · KG edge: associated_with
ATG5 — Autophagy Related 5
gene · KG edge: regulates

Knowledge Graph (12 edges)

VPS35 associated_with PARKIN
VPS35 associated_with DJ1
VPS35 associated_with VPS13D
VPS35 associated_with GBA
VPS35 associated_with VPS11
VPS35 associated_with PIK3C3
PRKN co_discussed VPS35
SNCA co_discussed VPS35
PARK7 co_discussed VPS35
PINK1 co_discussed VPS35

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