| Gene Symbol | CYP2D6 |
| Full Name | Cytochrome P450 2D6 |
| Protein Type | Enzyme |
| Function | encodes a crucial phase I drug-metabolizing enzyme that plays a pivotal role in the metabolism of approximately 25% of all clinically used drugs. |
| Molecular Weight | 56 kDa |
| Amino Acids | 497 aa |
| Pathways | Oxidative Stress |
| Ensembl ID | ENSG00000100168 |
| GeneCards | CYP2D6 |
| Human Protein Atlas | CYP2D6 |
| Catalytic reaction type | Hydroxylation, O-dealkylation, N-dealkylation |
| Cofactor requirement | NADPH-cytochrome P450 reductase |
| Substrate preference | Planar aromatic compounds with a nitrogen-containing basic group |
| Associated Diseases | ALS, Alzheimer, Alzheimer'S Disease, Anxiety |
| Known Drugs/Compounds | antidepressant drugs |
| Interactions | JUN, CHAT, SLC22A1, CHRNA7, PPAR, CYP3A4 |
| KG Connections | 265 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |