gene

CAMK2A

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CAMK2A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

127Connections
1Hypotheses
1Analyses
50Outgoing
32Incoming

Summary

Calcium/calmodulin-dependent protein kinase II alpha gene encoding a critical synaptic plasticity molecule with roles in LTP, memory, and neurodegeneration.

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🧬 Gene Info
Gene SymbolCAMK2A
Full NameCalcium/Calmodulin-Dependent Protein Kinase II Alpha
Protein TypeSerine/Threonine Kinase
FunctionCalcium/Calmodulin-Dependent Protein Kinase II alpha (CaMKIIα) is a serine/threonine kinase that serves as a central mediator of synaptic plasticity, learning, and memory
Molecular Weight54.1 kDa (monomer)
PathwaysHepatic Mitochondrial Oxidation, Intrahepatic Lipolysis, Neuronal Regeneration, Neuroregeneration, epigenetic regulation
UniProt ID[Q9UQM7](https://www.uniprot.org/uniprot/Q9UQM7)
GeneCardsCAMK2A
Human Protein AtlasCAMK2A
ProcessMechanism
[LTP](/mechanisms/long-term-potentiation) inductionCaMKII autophosphorylation at T286
LTD inductionProtein phosphatases reverse CaMKII action
[LTP](/mechanisms/long-term-potentiation) maintenancePersistent CaMKII activity
Memory consolidationCREB activation, gene transcription
ApproachAgent
Associated DiseasesALS, Epilepsy, Ms, Parkinson
Known Drugs/CompoundsCytosolic Calcium
InteractionsDLG4, FOS, PARP1, SYN1, NGF, SYNPO
SciDEX HypothesesCaMKII-Dependent Synaptic Circuit Amplification
KG Connections122 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

CAMK2A Gene

gene · 971 words

SETD1B

gene · 3299 words

calcineurin-signaling-pathway

mechanism · 3005 words

CFLAR

gene · 2704 words

Dorsolateral Prefrontal Cortex (DLPFC) Pyramidal Neurons

cell · 2690 words

GRIN2A Gene

gene · 2452 words

Pathway Diagram

graph TD
    CAMK2A["<b>CAMK2A</b>"]
    Ms{"Ms"}
    CAMK2A -->|"associated with"| Ms
    Parkinson{"Parkinson"}
    CAMK2A -->|"associated with"| Parkinson
    Als{"Als"}
    CAMK2A -->|"associated with"| Als
    CAMK2A -->|"expressed in"| Ms
    Depression{"Depression"}
    CAMK2A -->|"expressed in"| Depression
    ALS{"ALS"}
    CAMK2A -->|"associated with"| ALS
    SNCA["SNCA"]
    CAMK2A -->|"associated with"| SNCA
    SLC6A3["SLC6A3"]
    CAMK2A -->|"associated with"| SLC6A3
    UBC["UBC"]
    CAMK2A -->|"associated with"| UBC
    HOMER1["HOMER1"]
    CAMK2A -->|"associated with"| HOMER1
    COMT["COMT"]
    CAMK2A -->|"associated with"| COMT
    GENES["GENES"]
    CAMK2A -->|"associated with"| GENES
    DRD2["DRD2"]
    DRD2 -->|"associated with"| CAMK2A
    FYN["FYN"]
    FYN -->|"associated with"| CAMK2A
    SRC["SRC"]
    SRC -->|"associated with"| CAMK2A
    CLOCK["CLOCK"]
    CLOCK -->|"expressed in"| CAMK2A
    BMAL1["BMAL1"]
    BMAL1 -->|"expressed in"| CAMK2A
    PER["PER"]
    PER -->|"expressed in"| CAMK2A
    UBC -->|"associated with"| CAMK2A
    SNCA -->|"associated with"| CAMK2A
    AND["AND"]
    AND -->|"associated with"| CAMK2A
    GENES -->|"associated with"| CAMK2A
    COMT -->|"associated with"| CAMK2A
    PARKINSON["PARKINSON"]
    PARKINSON -->|"associated with"| CAMK2A
    style CAMK2A fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (95)

TargetRelationTypeStr
ds-f2c28aed24a7provides_data_fordataset1.00
Hepatic Mitochondrial Oxidationactivatesprocess0.95
Neuroregenerationinvolved_inprocess0.90
Necroinflammationinvolved_inprocess0.90
Neuronal Regenerationinvolved_inprocess0.85

Incoming (32)

SourceRelationTypeStr
ds-f2c28aed24a7data_indataset1.00
Cytosolic Calciumactivatescompound0.90
h-62c78d8btargets_genehypothesis0.90
GPR39activatesreceptor0.85
BDNFactivatesgene0.65

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
CaMKII-Dependent Synaptic Circuit Amplification 0.444 neuroscience Circuit-level neural dynamics in neurode

Mentioning Analyses (1)

Scientific analyses that reference this entity

Circuit-level neural dynamics in neurodegeneration

neuroscience | 2026-04-03 | 49 hypotheses Top: 0.709

Related Papers (5)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
Chaperone-mediated autophagy as a sex-specific modulator of synaptic proteostasi [PMID:41358563] Luo R Autophagy 2026 0
The mPFC molecular clock mediates the effects of sleep deprivation on depression [PMID:41023421] Gardner W, Sarrazin DH, Balzinger M, Mar Mol Psychiatry 2026 0
Sexually dimorphic cannabinoid 1 receptors on CaMKIIα neurons in the medial pref [PMID:41380094] Wang Q, Zhao J, Zhang X, Huang C, Li Y e Pain 2026 0
A bioinspired anisotropic anti-inflammatory scaffold enhances spinal nerve regen [PMID:41737465] Jiang M, Lu W, Zhuang J, Song J, Zhao Y Mater Today Bio 2026 0
A multi-omics comparison unveils convergent and divergent antidepressant mechani [PMID:41796893] Zhang J, Cai Y, Zhang P, Hao X, Guo B et J Proteomics 2026 0