gene

aldh1a3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about aldh1a3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

22Connections

0Hypotheses

0Analyses

9Outgoing

13Incoming

0Experiments

No summary available yet. View on Wiki →

🧬 Gene Info

Gene Symbol	Aldehyde Dehydrogenase 1 Family Member A3
Chromosome	15q26.3
Protein Family	Aldehyde dehydrogenase (ALDH) family
Protein Type	Enzyme
Function	is a member of the ALDH superfamily, which encompasses enzymes that catalyze the NAD(P)-dependent oxidation of aldehydes to carboxylic acids.
Molecular Weight	56 kDa
Amino Acids	512 aa
Gene Type	Protein-coding
UniProt ID	P47820
NCBI Gene ID	220
Ensembl ID	ENSG00000184254
OMIM	610463
Databases	GeneCards HPA STRING

🔮 Predicted Structure: aldh1a3 — AlphaFold P47820 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (4)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    ALDH1A3["ALDH1A3"]
    ALDH1A3 -->|"activates"| Glioblastoma["Glioblastoma"]
    ALDH1A3 -->|"expressed in"| Autophagy["Autophagy"]
    ALDH1A3 -->|"expressed in"| Glycolysis["Glycolysis"]
    ALDH1A3 -->|"expressed in"| Nf__b["Nf-Kappab"]
    ALDH1A3 -->|"expressed in"| Pi3K["Pi3K"]
    ALDH1A3 -->|"activates"| GLIOBLASTOMA["GLIOBLASTOMA"]
    ALDH1A3 -->|"activates"| XRCC1["XRCC1"]
    ALDH1A3 -->|"implicated in"| neurodegeneration["neurodegeneration"]
    VAMP7["VAMP7"] -->|"expressed in"| ALDH1A3
    MMP9["MMP9"] -->|"expressed in"| ALDH1A3
    PI3K["PI3K"] -->|"expressed in"| ALDH1A3
    NF__B["NF-KappaB"] -->|"expressed in"| ALDH1A3
    MCC["MCC"] -->|"expressed in"| ALDH1A3
    AUTOPHAGY["AUTOPHAGY"] -->|"expressed in"| ALDH1A3
    CXCR4["CXCR4"] -->|"expressed in"| ALDH1A3
    XRCC1 -->|"activates"| ALDH1A3

Outgoing (9)

Target	Relation	Type	Str
Glioblastoma	activates	disease	0.65
XRCC1	activates	gene	0.60
Autophagy	expressed_in	pathway	0.60
Glycolysis	expressed_in	pathway	0.60
Akt	associated_with	pathway	0.60
Nf-Κb	expressed_in	pathway	0.60
Pi3K	expressed_in	pathway	0.60
GLIOBLASTOMA	activates	gene	0.60
benchmark_ot_ad_answer_key:ALDH1A3	data_in	dataset_row	0.00

Incoming (13)

Source	Relation	Type	Str
GNAL	associated_with	gene	0.60
VAMP7	expressed_in	gene	0.60
MMP9	expressed_in	gene	0.60
PI3K	expressed_in	gene	0.60
AKT	associated_with	gene	0.60
AKT1	associated_with	gene	0.60
MCC	expressed_in	gene	0.60
CXCR4	expressed_in	gene	0.60
XRCC1	activates	gene	0.60
NF-ΚB	expressed_in	gene	0.60
AUTOPHAGY	expressed_in	gene	0.60
GLIOBLASTOMA	activates	gene	0.60
benchmark_ot_ad_answer_key:ALDH1A3	data_in	dataset_row	0.00

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found