gene 2,173 words KG: MCL1 2026-03-27
kind:genesection:genesstate:publishedtopic:mcl1topic:apoptosistopic:bcl2-familytopic:mitochondriatopic:neurodegenerationtopic:alzheimertopic:parkinson
Contents

MCL1 Gene - Myeloid Cell Leukemia 1

🧬 Gene Info
Gene SymbolMCL1
Full NameMyeloid Cell Leukemia 1
Chromosome1q21.2
Functionencodes a critical anti-apoptotic protein of the BCL2 family that plays essential roles in regulating mitochondrial outer membrane permeabilization (MOMP), cellular survival, and mitochondrial dyna...
Molecular Weight37 kDa
Amino Acids350 aa
PathwaysNF-κB
UniProt ID[Q07820](https://www.uniprot.org/uniprot/Q07820)
Ensembl IDENSG00000143384
GeneCardsMCL1
Human Protein AtlasMCL1
Associated DiseasesAD, ALI, ALS, AMI, Alzheimer
InteractionsBOK, VEGFA, SMARCA4, SF3B1, APOB, TERT
KG Connections320 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Knowledge Graph (12 edges)

MCL1 inhibits MDM4
MCL1 inhibits MET
MCL1 expressed_in BCL2
MCL1 expressed_in BCL2L1
MCL1 therapeutic_target VEGFA
MCL1 therapeutic_target MET
MCL1 interacts_with BOK
MCL1 therapeutic_target BAX
MCL1 associated_with MYC
MCL1 regulates APP