concept

FBXW7

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about FBXW7: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

181Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

FBXW7 is a concept in neurodegeneration research. Key relationships include: associated with, therapeutic target, regulates. Associated with Als, Cancer, Carcinoma. Connected to 77 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	FBXW7
Key Genes/Proteins	ZFP36, PPARGC1A
Related Diseases	Cancer, Carcinoma, Tumor, Ms, Als
Related Pathways	ubiquitin-proteasome

Wiki Pages (11)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    FBXW7["FBXW7"]
    FBXW7 -->|"inhibits"| ZFP36["ZFP36"]
    FBXW7 -->|"inhibits"| PPARGC1A["PPARGC1A"]
    FBXW7 -->|"interacts"| Ms["Ms"]
    FBXW7 -->|"target for"| Carcinoma["Carcinoma"]
    FBXW7 -->|"target for"| Cancer["Cancer"]
    FBXW7 -->|"target for"| Als["Als"]
    FBXW7 -->|"regulates"| Senescence["Senescence"]
    FBXW7 -->|"regulates"| Inflammation["Inflammation"]
    FBXW7 -->|"activates"| Ferroptosis["Ferroptosis"]
    LAMP2A["LAMP2A"] -->|"activates"| FBXW7
    TLR["TLR"] -->|"regulates"| FBXW7
    UBIQUITIN["UBIQUITIN"] -->|"activates"| FBXW7
    FERROPTOSIS["FERROPTOSIS"] -->|"activates"| FBXW7
    PIK3CA["PIK3CA"] -->|"target for"| FBXW7
    IDH1["IDH1"] -->|"target for"| FBXW7
    TP53["TP53"] -->|"target for"| FBXW7
    PI3K["PI3K"] -->|"target for"| FBXW7

Outgoing (113)

Target	Relation	Type	Str
ZFP36	inhibits	gene	0.90
ubiquitin-proteasome	participates_in	pathway	0.80
Cancer	therapeutic_target	disease	0.75
PPARGC1A	inhibits	protein	0.70
Carcinoma	associated_with	disease	0.65
Tumor	associated_with	disease	0.65
Ms	interacts_with	disease	0.65
Carcinoma	therapeutic_target	disease	0.65
Als	therapeutic_target	disease	0.65
Senescence	regulates	disease	0.65
Ms	regulates	disease	0.65
Inflammation	regulates	disease	0.65
Leukemia	associated_with	disease	0.65
Hepatocellular Carcinoma	associated_with	disease	0.65
Tumor	therapeutic_target	disease	0.65
Leukemia	activates	disease	0.65
Covid	interacts_with	disease	0.65
Neurodegeneration	activates	disease	0.65
Parkinson	activates	disease	0.65
Alzheimer	regulates	disease	0.65
Carcinoma	activates	disease	0.65
PTGS2	associated_with	gene	0.60
NCOA4	associated_with	gene	0.60
P53	associated_with	gene	0.60
TP53	associated_with	gene	0.60
BECN1	associated_with	gene	0.60
Autophagy	associated_with	pathway	0.60
Ferroptosis	activates	pathway	0.60
CANCER	therapeutic_target	gene	0.60
PTEN	associated_with	gene	0.60
ARID1A	associated_with	gene	0.60
CD14	regulates	gene	0.60
INFLAMMATION	regulates	gene	0.60
NF-ΚB	regulates	gene	0.60
PIEZO1	regulates	gene	0.60
DOT1L	regulates	gene	0.60
Nf-Κb	regulates	pathway	0.60
Toll-Like Receptor	regulates	pathway	0.60
Calcium Signaling	regulates	pathway	0.60
Hedgehog	regulates	pathway	0.60
P62	associated_with	gene	0.60
SQSTM1	associated_with	gene	0.60
SLC7A11	associated_with	gene	0.60
DNMT3A	therapeutic_target	gene	0.60
PHF6	therapeutic_target	gene	0.60
EP300	therapeutic_target	gene	0.60
NOTCH1	associated_with	gene	0.60
PIK3R1	therapeutic_target	gene	0.60
Notch	associated_with	pathway	0.60
Pi3K	therapeutic_target	pathway	0.60

Incoming (68)

Source	Relation	Type	Str
LAMP2A	activates	gene	0.70
SQSTM1	associated_with	gene	0.60
TNF	associated_with	gene	0.60
ELAVL1	associated_with	gene	0.60
GPX4	associated_with	gene	0.60
ATG	associated_with	gene	0.60
FN1	associated_with	gene	0.60
SLC7A11	associated_with	gene	0.60
ZFP36	associated_with	gene	0.60
FTH1	associated_with	gene	0.60
P62	associated_with	gene	0.60
MAP1LC3A	associated_with	gene	0.60
ARID1A	associated_with	gene	0.60
PTEN	associated_with	gene	0.60
PIK3CA	associated_with	gene	0.60
TP53	associated_with	gene	0.60
TLR	regulates	gene	0.60
NCOA4	associated_with	gene	0.60
UBIQUITIN	activates	gene	0.60
AUTOPHAGY	associated_with	gene	0.60
BECN1	associated_with	gene	0.60
P53	associated_with	gene	0.60
FERROPTOSIS	activates	gene	0.60
COL1A1	associated_with	gene	0.60
PIK3CA	therapeutic_target	gene	0.60
IDH1	therapeutic_target	gene	0.60
TP53	therapeutic_target	gene	0.60
PI3K	therapeutic_target	gene	0.60
ROS	associated_with	gene	0.60
CANCER	therapeutic_target	gene	0.60
MYC	activates	gene	0.60
AURKB	regulates	gene	0.60
MYC	regulates	gene	0.60
AND	regulates	gene	0.60
PTEN	inhibits	gene	0.60
AND	therapeutic_target	gene	0.60
INFLAMMATION	regulates	gene	0.60
DOT1L	regulates	gene	0.60
NF-ΚB	regulates	gene	0.60
AUTOPHAGY	regulates	gene	0.60
PARKINSON	activates	gene	0.60
ACLY	regulates	gene	0.60
ATP	contributes_to	gene	0.60
NEURODEGENERATION	activates	gene	0.60
VHL	activates	gene	0.60
TAU	regulates	gene	0.60
ACLY	activates	gene	0.60
ATP	activates	gene	0.60
CDK4	inhibits	gene	0.60
Autophagy	regulates	process	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

FBXW7

Understanding Entity Pages

Summary

Wiki Pages (11)

CDK6 Protein

LAMP2A Protein — Lysosomal-Associated Membrane Protein 2A

LAMP2A Gene

Thioflavin-T Fluorescence Assay for Protein Aggregation

MAML1 Gene — Mastermind-Like 1

Microglia Dysfunction: AD vs PD vs ALS vs FTD vs HD Comparison

LAMP2A Protein

ARID1A

HSP90AB1 Protein