concept

LKB1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about LKB1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

142Connections

0Hypotheses

0Analyses

50Outgoing

48Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	LKB1
Key Genes/Proteins	PD-1, AMPK, ACLY, SIRT1
Related Diseases	Insulin Resistance, Stroke, Obesity, Parkinson, Alzheimer

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    LKB1["LKB1"]
    LKB1 -->|"regulates"| PD_1["PD-1"]
    LKB1 -->|"regulates"| Mitochondrial_Homeostasis["Mitochondrial Homeostasis"]
    LKB1 -->|"activates"| AMPK["AMPK"]
    LKB1 -.protects against.-> Insulin_Resistance["Insulin Resistance"]
    LKB1 -->|"expressed in"| ILC2["ILC2"]
    LKB1 -->|"activates"| Parkinson["Parkinson"]
    LKB1 -->|"activates"| Alzheimer["Alzheimer"]
    LKB1 -->|"activates"| Obesity["Obesity"]
    ACLY["ACLY"] -->|"modifies"| LKB1
    Obesity -->|"inhibits"| LKB1
    AMPK -->|"activates"| LKB1
    MTORC1["MTORC1"] -->|"activates"| LKB1

Outgoing (94)

Target	Relation	Type	Str
PD-1	regulates	protein	0.95
Mitochondrial Homeostasis	regulates	process	0.92
AMPK	activates	protein	0.90
Insulin Resistance	protects_against	disease	0.90
ILC2	expressed_in	cell_type	0.85
MITOPHAGY	regulates	process	0.80
Stroke	contributes_to	disease	0.80
Parkinson	activates	disease	0.65
Alzheimer	activates	disease	0.65
Obesity	activates	disease	0.65
Alzheimer	inhibits	disease	0.65
Als	inhibits	disease	0.65
Multiple Sclerosis	inhibits	disease	0.65
Parkinson	inhibits	disease	0.65
ALS	inhibits	disease	0.65
AMPK	inhibits	protein	0.64
PARKINSON	activates	gene	0.60
AUTOPHAGY	activates	gene	0.60
RAPTOR	activates	gene	0.60
ATP	activates	gene	0.60
SNCA	activates	gene	0.60
AND	activates	gene	0.60
ACLY	activates	gene	0.60
ACETYL-COA	activates	gene	0.60
MTORC1	activates	gene	0.60
PARKINSON'S DISEASE	activates	gene	0.60
ALPHA-SYNUCLEIN	activates	gene	0.60
Autophagy	activates	pathway	0.60
Alpha-Synuclein	activates	pathway	0.60
Mtor	activates	pathway	0.60
ALZHEIMER DISEASE	activates	gene	0.60
ALZHEIMER	activates	gene	0.60
MAPT	activates	gene	0.60
AMYLOID	activates	gene	0.60
STK11	activates	gene	0.60
TAU	activates	gene	0.60
Amyloid	activates	pathway	0.60
Neuron	activates	cell_type	0.60
PD-1	expressed_in	gene	0.60
Mitophagy	activates	pathway	0.60
PARKINSON	inhibits	gene	0.60
Macrophage	associated_with	cell_type	0.60
INSULIN RESISTANCE	regulates	gene	0.60
MITOPHAGY	activates	gene	0.60
AND	regulates	gene	0.60
ALZHEIMER	inhibits	gene	0.60
AXON	inhibits	gene	0.60
AND	inhibits	gene	0.60
ALZHEIMER'S DISEASE	inhibits	gene	0.60
NEURODEGENERATIVE DISEASES	inhibits	gene	0.60

Incoming (48)

Source	Relation	Type	Str
ACLY	modifies	protein	0.85
Obesity	inhibits	disease	0.80
SIRT1	inhibits	protein	0.75
ACLY	regulates	protein	0.64
AMPK	activates	gene	0.60
ACLY	activates	gene	0.60
MTORC1	activates	gene	0.60
AUTOPHAGY	activates	gene	0.60
MITOPHAGY	activates	gene	0.60
AMPK	therapeutic_target	gene	0.60
TUBULIN	inhibits	gene	0.60
STK11	inhibits	gene	0.60
ALZHEIMER	inhibits	gene	0.60
PRKAA1	therapeutic_target	gene	0.60
AXON	inhibits	gene	0.60
PRKAA1	associated_with	gene	0.60
GENES	associated_with	gene	0.60
ATP	activates	gene	0.60
ACETYL-COA	activates	gene	0.60
ALPHA-SYNUCLEIN	activates	gene	0.60
MAPT	activates	gene	0.60
ALZHEIMER	activates	gene	0.60
SNCA	activates	gene	0.60
PD-1	expressed_in	gene	0.60
PARKINSON	inhibits	gene	0.60
AMPK	interacts_with	gene	0.60
metformin	targets	drug	0.60
CREB	interacts_with	gene	0.60
AMPK	regulates	gene	0.60
APP	regulates	gene	0.60
APP	activates	gene	0.60
ACTB	activates	gene	0.60
ATG	activates	gene	0.60
AURKB	activates	gene	0.60
CDK1	activates	gene	0.60
DDB1	activates	gene	0.60
GAPDH	activates	gene	0.60
GFP	activates	gene	0.60
GLB1	activates	gene	0.60
LC3B	activates	gene	0.60
rapamycin	targets	drug	0.60
AMPK	inhibits	gene	0.60
KRAS	inhibits	gene	0.60
AMPK	protects_against	gene	0.60
AMPK	associated_with	gene	0.60
DNA	activates	gene	0.60
AMPK	phosphorylates	gene	0.55
ATP	phosphorylates	gene	0.55

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

LKB1

Understanding Entity Pages

Wiki Pages (20)

Autophagy Mechanisms

AMPK Signaling Pathway

Sirtuin Signaling Pathway

Centrosome

DVL3 — Dishevelled Segment Polarity Protein 3

pard3

ACLY Inhibition Rescues Alpha-Synuclein Autophagy

AMPK Signaling in Neurodegeneration

PRKAA2 (AMPKα2) — AMP-Activated Protein Kinase Catalytic Subunit Alpha 2

AMPK Activators for Neurodegeneration

KIF13A Protein

MARK Tau Phosphorylation Pathway - Microtubule Affinity Regulating Kinase

Section 201: Advanced Mitochondrial Biogenesis and PGC-1α Targeting in CBS/PSP

PRKAB1 — Protein Kinase AMP-Activated Non-Catalytic Subunit Beta 1

MST4 Gene

PI3K-Akt Signaling in Parkinson's Disease

AMPK Signaling in Parkinson's Disease

cdkn2a