protein

ABETA

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ABETA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

40Connections
0Hypotheses
1Analyses
32Outgoing
3Incoming

No summary available yet. View on Wiki →

🔬 Protein Info
Gene SymbolABETA
PathwaysProtein Assembly
GeneCardsABETA
Human Protein AtlasABETA
AffiliationsUniversity of California San Diego
CountryUSA
H-index40
Research FocusAlzheimer's Disease
MechanismsAmyloid
Associated DiseasesAlzheimer's Disease
InteractionsNMDAR, AMPAR, Fyn, NR2B, GSK-3beta, CDK5
KG Connections35 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Ruth E. Abeta

researcher · 634 words

Novel Therapy Index

idea · 10647 words

Sleep and Circadian Dysfunction in Alzheimer's Disease

mechanism · 8066 words

Parthanatos in Neurodegeneration

mechanism · 6619 words

calcium-dysregulation-comparison

mechanism · 6468 words

Neuroresilience Mechanisms and Evidence

mechanism · 5775 words

Pathway Diagram

graph TD
    ABETA["ABETA"] -->|"causes"| Alzheimer_s_Disease["Alzheimer's Disease"]
    style Alzheimer_s_Disease fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    ABETA["ABETA"] -->|"involved in"| Protein_Assembly["Protein Assembly"]
    style Protein_Assembly fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    ABETA["ABETA"] -->|"component of"| Extracellular_Deposits["Extracellular Deposits"]
    style Extracellular_Deposits fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    ABETA["ABETA"] -->|"biomarker for"| Lewy_Pathology["Lewy Pathology"]
    style Lewy_Pathology fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    ABETA["ABETA"] -->|"regulates"| CA2["CA2"]
    style CA2 fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    ABETA["ABETA"] -->|"co discussed"| TAU["TAU"]
    style TAU fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    ABETA["ABETA"] -->|"co discussed"| ALZHEIMER["ALZHEIMER"]
    style ALZHEIMER fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    LEPTIN["LEPTIN"] -->|"regulates"| ABETA["ABETA"]
    style LEPTIN fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    GD3_synthase["GD3 synthase"] -->|"interacts"| ABETA["ABETA"]
    style GD3_synthase fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    style ABETA fill:#006494,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold

Outgoing (35)

TargetRelationTypeStr
Alzheimer's Diseasecausesdisease0.95
Protein Assemblyinvolved_inprocess0.90
Extracellular Depositscomponent_ofphenotype0.90
Lewy Pathologybiomarker_forphenotype0.85
synapse turnoverassociated_withprocess0.80

Incoming (5)

SourceRelationTypeStr
LEPTINregulatesprotein0.80
GD3 synthaseinteracts_withgene0.80
LEPTINinhibitsprotein0.70

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

Lysosomal dysfunction and cathepsin leakage in Alzheimer disease progression

neuroscience | 2026-04-04 | 0 hypotheses

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found