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mechanism 1,456 words KG: GABA 2026-04-01
kind:mechanismsection:mechanismsstate:published
Contents

GABA Imbalance in Neurodegeneration

⚙ Mechanism Info
NameGABA Imbalance in Neurodegeneration
SummaryGABA imbalance and its role in neurodegenerative diseases including Alzheimer's, Parkinson's, and Huntington's disease
Key Genes/ProteinsGABARAP, LC3, MTOR, TFEB, RNA, ULK1
Related DiseasesALZHEIMER'S DISEASE
Related Pathwaysoxidative stress response
Linked Hypotheses7 hypotheses

Knowledge Graph

Related Hypotheses (30)

SASP-Mediated Complement Cascade Amplification
Score: 0.70Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.67Transcriptional Autophagy-Lysosome Coupling
Score: 0.66Selective Acid Sphingomyelinase Modulation Therapy
Score: 0.65CYP46A1 Overexpression Gene Therapy
Score: 0.63

Related Analyses (30)

Metabolomic signatures of neurodegeneration and energy metab
neurodegeneration · failedSelective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archived4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archivedTDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archivedAstrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived

Related Experiments (30)

Metabolic Pathway-Targeted Therapy in ALS
clinical · proposed · Score: 0.40Experiment: Autoimmune Hypothesis Testing in AD
clinical · proposed · Score: 0.40ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40Non-Dopaminergic Neurotransmitter Degeneration in PD - Exper
clinical · proposed · Score: 0.40Proposed experiment from debate on Astrocytes adopt A1 (neur
falsification · proposed · Score: 0.40

See Also (15)

Wnt/β-Catenin Signaling Pathway in Neurodegeneration
mechanism · Pages share 139 hypothesesWNK1 Kinase in Neurodegeneration
mechanism · Pages share 139 hypothesesWNK1-Bilirubin Signaling in Neuroinflammation and Neuro
mechanism · Pages share 139 hypothesesvip-vasoactive-intestinal-peptide-signaling-neurodegene
mechanism · Pages share 139 hypothesesVEGF Signaling and Cerebral Angiogenesis in Neurodegene
mechanism · Pages share 139 hypotheses

Knowledge Graph (12 edges)

GABA co_discussed JNK
GABA co_discussed LC3
GABA co_discussed LRRK2
GABA co_discussed MTOR
GABA co_discussed ULK1
GABA co_discussed HISTONE
GABA co_discussed ISCHEMIA
GABA co_discussed HTT
GABA co_discussed MITOCHONDRIA
GABA co_discussed MITOPHAGY
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