protein 945 words KG: CAMK2A 2026-03-21
kind:proteinsection:proteinsstate:published
Contents

CaMKII Protein (CaMK2A)

🔬 Protein Info
Gene SymbolCAMK2A
Full NameCalcium/Calmodulin-Dependent Protein Kinase II Alpha
Protein TypeSerine/Threonine Kinase
FunctionCalcium/Calmodulin-Dependent Protein Kinase II alpha (CaMKIIα) is a serine/threonine kinase that serves as a central mediator of synaptic plasticity, learning, and memory
Molecular Weight54.1 kDa (monomer)
PathwaysHepatic Mitochondrial Oxidation, Intrahepatic Lipolysis, Neuronal Regeneration, Neuroregeneration, epigenetic regulation
UniProt ID[Q9UQM7](https://www.uniprot.org/uniprot/Q9UQM7)
GeneCardsCAMK2A
Human Protein AtlasCAMK2A
Associated DiseasesALS, Epilepsy, Ms, Parkinson
Known Drugs/CompoundsCytosolic Calcium
InteractionsDLG4, FOS, PARP1, SYN1, NGF, SYNPO
SciDEX HypothesesCaMKII-Dependent Synaptic Circuit Amplification
KG Connections122 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (13)

CaMKII-Dependent Synaptic Circuit Amplification
Score: 0.44
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.68
Chromatin Accessibility Restoration via BRD4 Modulation
Score: 0.56
Circadian Clock-Autophagy Synchronization
Score: 0.55
Temporal Decoupling via Circadian Clock Reset
Score: 0.52

Related Analyses (13)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
Sleep disruption as cause and consequence of neurodegenerati
neurodegeneration · archived

Related Experiments (5)

Bmal1 knockout in mPFC excitatory neurons
validation · proposed · Score: 0.95
Sex differences in CB1R-mediated cannabinoid analgesia in ne
validation · proposed · Score: 0.90
Conditional CB1R knockout in mPFC CaMKIIα neurons
validation · proposed · Score: 0.90
Electrophysiological analysis of mPFC-vlPAG synaptic transmi
exploratory · proposed · Score: 0.85
CB1R expression mapping in mPFC-vlPAG circuit
exploratory · proposed · Score: 0.85

See Also (6)

Packard Center for ALS Research
institution · KG edge: associated_with
APP Gene Dosage Reduction Therapy for Down Syndrome
idea · KG edge: associated_with
FYN — FYN Proto-Oncogene, Src Family Tyrosine Kinase
gene · KG edge: associated_with
DRD2 Gene
gene · KG edge: associated_with
COMT Gene
gene · KG edge: associated_with

Knowledge Graph (12 edges)

CAMK2A associated_with SNCA
CAMK2A associated_with SLC6A3
CAMK2A associated_with UBC
CAMK2A associated_with HOMER1
CAMK2A associated_with COMT
CAMK2A associated_with FYN
CAMK2A associated_with SRC
CAMK2A associated_with DRD2
CAMK2A co_discussed SNCA
CAMK2A co_discussed FYN