protein 1,291 words KG: CCR5 2026-03-27
kind:proteinsection:proteinsstate:published
Contents

CCR5 Protein

🔬 Protein Info
Gene SymbolCCR5
AliasesCCR5 chemokine receptor
Protein TypeGene
FunctionCCR5 is a seven-transmembrane G protein-coupled receptor that binds CCL3 (MIP-1α), CCL4 (MIP-1β), and CCL5 (RANTES).
Molecular Weight46 kDa
Amino Acids352 aa
PathwaysMAPK, PI3K
UniProt IDP51681
GeneCardsCCR5
Human Protein AtlasCCR5
Associated DiseasesALS, Alzheimer, Inflammation, Neuroinflammation, Ptsd
InteractionsPI3K, APP, CCL5, FIS1, NLRP3, CCL4
KG Connections283 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (5)

APOE-Dependent Autophagy Restoration
Score: 0.61
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.51
Astrocyte-Mediated Neuronal Epigenetic Rescue
Score: 0.48
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.42
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.35

Related Analyses (7)

Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Epigenetic reprogramming in aging neurons
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (1)

Proposed experiment from debate on Synaptic pruning by micro
falsification · proposed · Score: 0.40

See Also (7)

Alzheimer Indonesia
institution · KG edge: interacts_with
CCL3 Gene
gene · KG edge: activates
C3AR1 Gene
gene · KG edge: associated_with
ADCY2 — Adenylate Cyclase 2
gene · KG edge: associated_with
ABCA1 - ATP-Binding Cassette Transporter A1
gene · KG edge: regulates

Knowledge Graph (12 edges)

CCR5 activates TAU
CCR5 activates PI3K
CCR5 interacts_with APP
CCR5 inhibits CCL5
CCR5 interacts_with FIS1
CCR5 activates NLRP3
CCR5 activates CCL4
CCR5 therapeutic_target OVERVIEW
CCR5 therapeutic_target STING
CCR5 activates CCL5