concept

N-ACETYLCYSTEINE

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about N-ACETYLCYSTEINE: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

74Connections

0Hypotheses

0Analyses

43Outgoing

24Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	N-ACETYLCYSTEINE
Key Genes/Proteins	GPX4, CDK5, ROS, KEAP1, HMOX1, LAMP1
Related Diseases	NEURODEGENERATION, FERROPTOSIS, OXIDATIVE STRESS

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    N_ACETYLCYSTEINE["N-ACETYLCYSTEINE"]
    N_ACETYLCYSTEINE -->|"inhibits"| Ferroptosis["Ferroptosis"]
    N_ACETYLCYSTEINE -->|"inhibits"| ROS["ROS"]
    N_ACETYLCYSTEINE -->|"treats"| Herpes_Simplex_Keratitis["Herpes Simplex Keratitis"]
    N_ACETYLCYSTEINE -->|"inhibits"| Disulfidptosis["Disulfidptosis"]
    N_ACETYLCYSTEINE -->|"targets"| Oxidative_Stress["Oxidative Stress"]
    N_ACETYLCYSTEINE -->|"activates"| TNF["TNF"]
    JNK["JNK"] -->|"activates"| N_ACETYLCYSTEINE
    APOPTOSIS["APOPTOSIS"] -->|"activates"| N_ACETYLCYSTEINE
    MICRORNA_REGULATION["MICRORNA REGULATION"] -->|"target for"| N_ACETYLCYSTEINE
    ERK["ERK"] -->|"activates"| N_ACETYLCYSTEINE
    HYPERTENSION["HYPERTENSION"] -->|"activates"| N_ACETYLCYSTEINE
    MAPK["MAPK"] -->|"activates"| N_ACETYLCYSTEINE
    GLIOSIS["GLIOSIS"] -->|"activates"| N_ACETYLCYSTEINE
    AXON["AXON"] -->|"activates"| N_ACETYLCYSTEINE

Outgoing (50)

Target	Relation	Type	Str
NEURODEGENERATION	protects_against	phenotype	0.70
FERROPTOSIS	targets	phenotype	0.65
CDK5	treats	gene	0.65
CDK5	activates	gene	0.65
CDK5	inhibits	gene	0.65
ROS	activates	protein	0.50
ROS	therapeutic_target	protein	0.50
GPX4	associated_with	gene	0.50
OXIDATIVE STRESS	associated_with	phenotype	0.50
KEAP1	associated_with	gene	0.50
HMOX1	associated_with	gene	0.50
LAMP1	associated_with	gene	0.50
MTOR	associated_with	gene	0.50
TFEB	associated_with	gene	0.50
NRF2	associated_with	gene	0.50
HO-1	associated_with	gene	0.50
RIPK1	associated_with	gene	0.50
DEFEROXAMINE	associated_with	drug	0.45
FERROPTOSIS	associated_with	phenotype	0.45
APOPTOSIS	associated_with	phenotype	0.45
ROS	associated_with	phenotype	0.45
GLIOSIS	associated_with	phenotype	0.45
MAPK	associated_with	gene	0.45
JNK	associated_with	gene	0.45
SORAFENIB	associated_with	drug	0.45
TNF	associated_with	gene	0.45
TAU	associated_with	protein	0.45
NAC	associated_with	drug	0.45
P38	associated_with	gene	0.45
PYROPTOSIS	associated_with	phenotype	0.45
SULFORAPHANE	associated_with	drug	0.45
RAPAMYCIN	associated_with	drug	0.45
INFLAMMATION	associated_with	phenotype	0.45
NECROPTOSIS	associated_with	phenotype	0.45
DEFERIPRONE	associated_with	drug	0.45
CDK5	associated_with	gene	0.45
TNF	activates	gene	0.35
NEURODEGENERATION	activates	process	0.35
NEUROINFLAMMATION	activates	process	0.35
P38	activates	gene	0.35
NUCLEUS ACCUMBENS	regulates	brain_region	0.35
SORAFENIB	inhibits	drug	0.35
TNF	inhibits	gene	0.35

Incoming (24)

Source	Relation	Type	Str
GPX4	activates	gene	0.70
JNK	activates	gene	0.50
APOPTOSIS	activates	process	0.50
NEURODEGENERATION	associated_with	phenotype	0.50
APOPTOSIS	associated_with	phenotype	0.45
DEFEROXAMINE	associated_with	drug	0.45
FERROPTOSIS	associated_with	phenotype	0.45
GLIOSIS	associated_with	phenotype	0.45
JNK	associated_with	gene	0.45
MAPK	associated_with	gene	0.45
MICRORNA REGULATION	therapeutic_target	process	0.35
ERK	activates	gene	0.35
HYPERTENSION	activates	disease	0.35
MAPK	activates	gene	0.35
GLIOSIS	activates	process	0.35
GSH	activates	gene	0.35
GLIOSIS	inhibits	process	0.35
GLAUCOMA	protects_against	disease	0.35
GLIOSIS	protects_against	process	0.35
FERROPTOSIS	activates	process	0.35
AUTOPHAGY	activates	process	0.35
AUTOPHAGY	associated_with	process	0.35
CHRNA7	regulates	gene	0.35
CHRNA7	expressed_in	gene	0.35

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

N-ACETYLCYSTEINE

Understanding Entity Pages

Wiki Pages (20)

cbs-psp-daily-action-plan

Personalized Treatment Plan — Atypical Parkinsonism (CBS/PSP)

Progressive Supranuclear Palsy (PSP)

Corticobasal Syndrome (CBS)

CBS/PSP Supplements Guide

Alpha-Synuclein Pathology

Section 162: Advanced Antioxidant and Redox Therapy in CBS/PSP

CBS/PSP Treatment Rankings

ALS Failed Approaches Analysis

protective-strategies-cbs-psp

deferiprone-neurodegeneration

Ferroptosis in Alzheimer's Disease

Neuronal Ceroid Lipofuscinosis (NCL)

metal-ion-synuclein-mitochondria-axis-parkinsons

Neuroprotection Strategies in Neurodegeneration

NACET (N-Acetylcysteine Ethyl Ester)

Neuroinflammation-Mitochondria Crosstalk Pathway

Lipid Peroxidation in Neurodegeneration