| Gene Symbol | CREB |
| Aliases | CREBPROTEIN |
| Function | Creb Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes. |
| Primary Expression | hippocampus, cortex, prefrontal cortex, striatum, Prefrontal Cortex |
| Molecular Weight | 37 kDa |
| Amino Acids | 341 aa |
| Pathways | Methamphetamine Toxicity |
| GeneCards | CREB |
| Human Protein Atlas | CREB |
| Kinase-inducible domain (KID) | Contains serine-133, the primary site for phosphorylation-dependent activation |
| Basic region | DNA-binding domain that recognizes CRE (cAMP response element) sequences |
| Leucine zipper (bZIP) | Dimerization domain that allows CREB to form homodimers or heterodimers with other ATF/CREB proteins |
| Immediate-early genes | c-Fos, Egr-1, Arc |
| Neurotrophic factors | BDNF, NGF |
| Anti-apoptotic proteins | Bcl-2, Mcl-1 |
| Associated Diseases | ALS, Alzheimer, Alzheimer's disease, Cardiomyopathy, CHROMATIN REMODELING |
| Known Drugs/Compounds | EPIGALLOCATECHIN GALLATE, GENISTEIN, ketamine, Ketogenic Diet, LIRAGLUTIDE, memantine |
| Interactions | ABETA, ACAT1, ACHE, ACOX1, Actin, AD |
| KG Connections | 1877 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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