protein 2,821 words KG: CXCR4
Contents

CXCR4 Protein

🔬 Protein Info
Gene SymbolCXCR4
AliasesC-X-C chemokine receptor type 4
Chromosome2q22.1
Protein TypeReceptor
FunctionCXCR4 has diverse physiological roles
Molecular Weight39.8 kDa
Amino Acids352 aa
PathwaysNF-κB, PI3K, MAPK pathway, MAPK
GeneCardsCXCR4
Human Protein AtlasCXCR4
Associated DiseasesAls, Alzheimer, Autoimmune, Breast Cancer, Cancer, Inflammation
InteractionsSIRT1, CXCL12, HSPA1A, PSD95, MTOR, SYNAPTOPHYSIN
KG Connections316 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (21)

Ocular Immune Privilege Extension
Score: 0.47
Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.67
Selective TLR4 Modulation to Prevent Gut-Derived Neuroinflam
Score: 0.62
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.59
Competitive APOE4 Domain Stabilization Peptides
Score: 0.56

Related Analyses (6)

Digital biomarkers and AI-driven early detection of neurodeg
neurodegeneration · archived
Synaptic pruning by microglia in early AD
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Epigenetic reprogramming in aging neurons
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (9)

Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: inhibits
Alzheimer Indonesia
institution · KG edge: expressed_in
APOE contributes to Alzheimer's disease by regulating b
hypothesis · KG edge: inhibits
BCL2 Gene
gene · KG edge: associated_with
ATF6 - Activating Transcription Factor 6
gene · KG edge: associated_with

Knowledge Graph (12 edges)

CXCR4 activates SIRT1
CXCR4 regulates STING
CXCR4 expressed_in ALDH1A3
CXCR4 treats MTOR
CXCR4 treats CCR5
CXCR4 associated_with NAMPT
CXCR4 interacts_with CXCL12
CXCR4 associated_with LAMP1
CXCR4 associated_with VEGFA
CXCR4 inhibits HSPA1A