| Gene Symbol | DNMT1 |
| Aliases | DNMT1PROTEIN |
| Chromosome | 19p13.2<br> |
| Protein Type | Epigenetic Regulator |
| Target Class | Epigenetic Regulator |
| Function | DNMT1 maintains DNA methylation patterns by copying methylation from the parental DNA strand to the newly synthesized strand. |
| Mechanism of Action | Small molecule inhibitor of DNA methyltransferase activity |
| Primary Expression | all tissues with high expression in:
- Developing brain (neurons and progenitors)
- Adult hippocampus (CA1, dentate gyrus)
- Cere |
| Subcellular Localization | </strong></td><td>Nucleus</td></tr> |
| Druggability | Medium (0.52) |
| Clinical Stage | Approved |
| Molecular Weight | 183 kDa |
| Pathways | Differentiation, Epigenetic, Immune Response |
| UniProt ID | P26358 |
| NCBI Gene ID | 1785 |
| Ensembl ID | ENSG00000123091 |
| GeneCards | DNMT1 |
| Human Protein Atlas | DNMT1 |
| Associated Diseases | ALS, ALZHEIMER'S DISEASE, Amyotrophic Lateral Sclerosis, Ataxia |
| Known Drugs/Compounds | RAPAMYCIN, rapamycin |
| Interactions | SNCA, HSPA1A, DKK1, DNMT3B, BDNF, MDM2 |
| SciDEX Target | View Target Profile (8 clinical trials) |
| SciDEX Hypotheses | DNMT1-Targeting Antisense Oligonucleotide Reset |
| KG Connections | 443 knowledge graph edges |
| Databases | GeneCardsHPASTRING |