protein 2,596 words KG: HDAC7
Contents

HDAC7 Protein

🔬 Protein Info
Gene SymbolHDAC7
Chromosome12q13
Protein TypeGene
Functionis a Class IIa histone deacetylase that plays crucial roles in gene regulation, cellular signaling, and neuronal function.
Subcellular Localization</strong></td><td>Primarily cytoplasm, translocates to nucleus upon signaling</td></tr>
Molecular Weight103 kDa
Amino Acids669 aa
PathwaysOxidative Stress
GeneCardsHDAC7
Human Protein AtlasHDAC7
Associated DiseasesALS, Cell Transformation, Tumor
InteractionsAKT, ALS, AMPK, AND, ATM, AXIN1
KG Connections135 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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🌐 Cross-references

UniProtWikipedia

Related Hypotheses (15)

Astrocyte-Mediated Neuronal Epigenetic Rescue
Score: 0.73
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82
Selective HDAC3 Inhibition with Cognitive Enhancement
Score: 0.78
SIRT3-Mediated Mitochondrial Deacetylation Failure with PINK
Score: 0.74
Phase-Separated Organelle Targeting
Score: 0.73
Stress Granule Phase Separation Modulators
Score: 0.72
HDAC3-Selective Inhibition for Clock Reset
Score: 0.71
Mitochondrial-Nuclear Epigenetic Cross-Talk Restoration
Score: 0.70
Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.70
Chaperone-Mediated APOE4 Refolding Enhancement
Score: 0.68
RNA Granule Nucleation Site Modulation
Score: 0.66
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62
SIRT6-NAD+ Axis Enhancement Therapy
Score: 0.61

Related Analyses (9)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Epigenetic clocks and biological aging in neurodegeneration
neurodegeneration · archived
Epigenetic reprogramming in aging neurons
neurodegeneration · archived

Related Experiments (3)

Epigenetic Dysregulation in Huntington's Disease — Therapeut
validation · completed · Score: 0.40
Epigenetic Regulation Dysfunction in Alzheimer's and Parkins
clinical · proposed · Score: 0.40
Microglial Contributions to Huntington's Disease Pathogenesi
validation · proposed · Score: 0.40

See Also (9)

AMPK (AMP-Activated Protein Kinase)
entity · KG edge: inhibits
Genes
index · KG edge: associated_with
ATM Gene
gene · KG edge: inhibits
AXIN1 Gene
gene · KG edge: inhibits
BDNF Gene
gene · KG edge: regulates

Knowledge Graph (12 edges)

HDAC7 therapeutic_target PTEN
HDAC7 associated_with HDAC4
JUN activates HDAC7
MEF2D regulates HDAC7
HDAC7 regulates myelination
JUN associated_with HDAC7
PTEN therapeutic_target HDAC7
PI3K therapeutic_target HDAC7
HDAC4 associated_with HDAC7
AKT therapeutic_target HDAC7

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