protein 2,596 words KG: HDAC7 2026-03-27
kind:proteinsection:proteinsstate:published
Contents

HDAC7 Protein

🔬 Protein Info
Gene SymbolHDAC7
Chromosome12q13
Protein TypeGene
Functionis a Class IIa histone deacetylase that plays crucial roles in gene regulation, cellular signaling, and neuronal function.
Subcellular Localization</strong></td><td>Primarily cytoplasm, translocates to nucleus upon signaling</td></tr>
Molecular Weight103 kDa
Amino Acids669 aa
PathwaysOxidative Stress
GeneCardsHDAC7
Human Protein AtlasHDAC7
Associated DiseasesALS, Cell Transformation, Tumor
InteractionsAKT, UBIQUITIN, TAU, NEURODEGENERATIVE DISEASES, MEF2, MYC
KG Connections138 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (15)

Astrocyte-Mediated Neuronal Epigenetic Rescue
Score: 0.48
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.68
Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.67
Selective HDAC3 Inhibition with Cognitive Enhancement
Score: 0.56
Phase-Separated Organelle Targeting
Score: 0.52

Related Analyses (9)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Epigenetic clocks and biological aging in neurodegeneration
neurodegeneration · archived
Epigenetic reprogramming in aging neurons
neurodegeneration · archived

Related Experiments (3)

Epigenetic Dysregulation in Huntington's Disease — Therapeut
validation · proposed · Score: 0.40
Epigenetic Regulation Dysfunction in Alzheimer's and Parkins
clinical · proposed · Score: 0.40
Microglial Contributions to Huntington's Disease Pathogenesi
validation · proposed · Score: 0.40

See Also (9)

Packard Center for ALS Research
institution · KG edge: inhibits
Alzheimer Indonesia
institution · KG edge: regulates
G3BP1
gene · KG edge: inhibits
CD4 Gene
gene · KG edge: activates
BDNF Gene
gene · KG edge: regulates

Knowledge Graph (12 edges)

HDAC7 provides_data_for ds-83b31ef18d49
HDAC7 therapeutic_target PTEN
HDAC7 associated_with HDAC4
HDAC7 therapeutic_target PI3K
HDAC7 regulates SIRT4
HDAC7 regulates SIRT7
HDAC7 expressed_in HDAC6
HDAC7 regulates SIRT2
HDAC7 regulates SIRT1
HDAC7 expressed_in HDAC1