protein 884 words KG: LRP1B 2026-03-21
kind:proteinsection:proteinsstate:published
Contents

LRP1B Protein

🔬 Protein Info
Gene SymbolLRP1B
Full NameLRP1B
AliasesPage for LRP1B Protein
Chromosome2q22.1
Protein TypeProtein
Functionis a very large LDL receptor-family transmembrane protein that functions as an endocytic and signaling regulator in epithelial and neuronal systems.
Molecular Weight500 kDa
Amino Acids595 aa
Exons92
PathwaysMAPK, PI3K, Wnt signaling
UniProt IDSearch UniProt
GeneCardsLRP1B
Human Protein AtlasLRP1B
Associated DiseasesALS, Aging, Atherosclerosis, Cancer, Cardiovascular
InteractionsPAH, APOE, WNT, CANCER, APOPTOSIS, PD-1
KG Connections100 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (16)

Synthetic Biology BBB Endothelial Cell Reprogramming
Score: 0.57
Circadian-Synchronized LRP1 Pathway Activation
Score: 0.53
Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides
Score: 0.51
LRP1-Dependent Tau Uptake Disruption
Score: 0.44
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.59

Related Analyses (9)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived

Related Experiments (3)

Anti-Tau Immunotherapy Dosing Optimization
clinical · proposed · Score: 0.40
Tau PET Pattern as Therapeutic Response Predictor in 4R-Tauo
clinical · proposed · Score: 0.40
Tau Propagation Causality Test — Does Tau Spread Drive Neuro
clinical · proposed · Score: 0.40

See Also (15)

Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: associated_with
Packard Center for ALS Research
institution · KG edge: associated_with
LRP1-Enhanced Perivascular Drainage Therapy
idea · KG edge: associated_with
LDLR Gene
gene · KG edge: associated_with
EGFR — Epidermal Growth Factor Receptor
gene · KG edge: associated_with

Knowledge Graph (12 edges)

LRP1B associated_with LRP4
LRP1B associated_with PAH
LRP1B associated_with LDLR
LRP1B associated_with LRP5
LRP1B associated_with LRP1
LRP1B associated_with LRP8
LRP1B associated_with LRP2
LRP1B associated_with RYR2
LRP1B associated_with EGFR
LRP1B associated_with TP53