protein 2,294 words KG: LRPPRC 2026-03-21
kind:proteinsection:proteinsstate:published
Contents

LRPPRC Protein

🔬 Protein Info
Gene SymbolLRPPRC
Chromosome2p21
FunctionLRPPRC encodes a leucine-rich pentatricopeptide repeat (PPR) protein that localizes to mitochondria and is involved in post-transcriptional regulation of mitochondrial gene expression.
Subcellular Localization</strong></td><td>Mitochondria</td></tr>
Molecular Weight156 kDa
Amino Acids394 aa
Exons38
PathwaysOxidative Phosphorylation
Ensembl IDENSG00000138095
GeneCardsLRPPRC
Human Protein AtlasLRPPRC
Associated DiseasesAls, Parkinson
Known Drugs/CompoundsDuloxetine, Donepezil, donepezil
InteractionsACO2, HSPA9, SNCA, SDHA, VDAC1, CYCS
KG Connections106 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (8)

Near-infrared light therapy stimulates COX4-dependent mitoch
Score: 0.51
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.51
Cryptic Exon Silencing Restoration
Score: 0.46
Cross-Seeding Prevention Strategy
Score: 0.45
Glycine-Rich Domain Competitive Inhibition
Score: 0.43

Related Analyses (6)

Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · completed

See Also (10)

Packard Center for ALS Research
institution · KG edge: stabilizes
HSPA9 Gene
gene · KG edge: therapeutic_target
GLUD1 - Glutamate Dehydrogenase 1
gene · KG edge: associated_with
DOCK2 Gene
gene · KG edge: associated_with
CYCS
gene · KG edge: therapeutic_target

Knowledge Graph (12 edges)

LRPPRC interacts_with BECN1
LRPPRC associated_with NDUFS2
LRPPRC associated_with NDUFS1
LRPPRC therapeutic_target SDHA
LRPPRC therapeutic_target HERC5
LRPPRC therapeutic_target UBIQUITIN
LRPPRC therapeutic_target RNF5
LRPPRC therapeutic_target ACO2
LRPPRC causes NDUFS2
LRPPRC causes GLUD1