protein 642 words KG: PP2APROTEIN 2026-03-21
kind:proteinsection:proteinsstate:published
Contents

PP2A Protein

🔬 Protein Info
Gene SymbolPP2A
Full NameProtein Phosphatase 2 Scaffold Subunit A Alpha
AliasesPPP2R1A
Chromosome19q13.41
Protein TypeProtein
Molecular Weight65 kDa
PathwaysWnt, Notch pathway, mTOR, mtor, Wnt signaling
UniProt IDP30153
NCBI Gene ID5518
Ensembl IDENSG00000114825
OMIM605983
GeneCardsPP2A
Human Protein AtlasPP2A
Associated DiseasesAging, Als, Alzheimer, Alzheimer's disease, Neurodegeneration, Senescence
Known Drugs/CompoundsDonepezil, donepezil, resveratrol, rapamycin, metformin, DONEPEZIL
InteractionsGAIN, ERK1, NRF2, KEAP1, PTEN, SQSTM1
KG Connections351 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (9)

AMPK hypersensitivity in astrocytes creates enhanced mitocho
Score: 0.57
Circadian Glymphatic Rescue Therapy (Melatonin-focused)
Score: 0.55
Astroglial Gap Junction Coordination via Connexin-43 Phospho
Score: 0.50
Sphingomyelin Synthase Activators for Raft Remodeling
Score: 0.47
VCP-Mediated Autophagy Enhancement
Score: 0.41

Related Analyses (11)

Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Sleep disruption as cause and consequence of neurodegenerati
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Epigenetic clocks and biological aging in neurodegeneration
neurodegeneration · archived
Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived

See Also (15)

Neurodegeneration
disease · KG edge: implicated_in
Wnt/β-Catenin Signaling Pathway in Neurodegeneration
mechanism · Pages share 5 hypotheses
WNK1-Bilirubin Signaling in Neuroinflammation and Neuro
mechanism · Pages share 5 hypotheses
vip-vasoactive-intestinal-peptide-signaling-neurodegene
mechanism · Pages share 5 hypotheses
VEGF Signaling and Cerebral Angiogenesis in Neurodegene
mechanism · Pages share 5 hypotheses